Angelo Lombardo

San Raffaele Telethon Institute for Gene Therapy, Italy

Angelo Lombardo (PhD) is Group Leader at the San Raffaele Telethon Institute for Gene Therapy (SR-Tiget) and Assistant Professor of Tissue Biology at the Vita-Salute San Raffaele University, Milan, Italy. During his PhD and Postdoctoral studies, he significantly contributed to the field of targeted genome editing by developing innovative gene transfer technologies for the delivery of artificial nucleases, exploiting them in relevant disease models and characterizing their genome-wide specificity. His research now focuses on targeted epigenetic editing, a novel technology that exploits engineered transcriptional repressors to permanently silence genes of therapeutic relevance. His lab is also using these tools to study basic principles of gene regulation and transmission of epigenetic information.

Presentation(s):

• 1 - TOPIC OVERVIEW BY CHAIR

  6/21/2018
  16:00 – 16:05

• 2 - EXPLOITING TARGETED (EPI)GENOME EDITING FOR THERAPEUTIC APPLICATIONS

  6/22/2018
  09:25 – 09:50

Haoyi Wang

Institute of Zoology, Chinese Academy of Sciences, China

Dr. Haoyi Wang set up his own lab at the Institute of Zoology, Chinese academy of Sciences in 2014 as a principal investigator. His lab focuses on developing novel technologies to achieve more efficient and specific genome and epigenome editing, and applying them to generate genetically modified animal models and establish novel therapeutic approaches. Since its establishment, Wang lab has developed “ZEN” method for high throughput delivery of CRISPR reagent into mouse zygotes, established “Casilio” method for transcription and epigenetic regulation, and achieved efficient multiplex gene editing in CAR-T cells. Another main research interest of the lab is to study the characteristics of naïve pluripotency in human embryonic stem cells.

Presentation(s):

• 2 - GENE EDITING: OPTIMIZATION AND APPLICATION IN PRIMARY CELLS

  6/21/2018
  16:05 – 16:30

Wei Mu

Presentation(s):

• 2 - GENE EDITING: OPTIMIZATION AND APPLICATION IN PRIMARY CELLS

  6/21/2018
  16:05 – 16:30

Guanghai Xiang

Presentation(s):

• 2 - GENE EDITING: OPTIMIZATION AND APPLICATION IN PRIMARY CELLS

  6/21/2018
  16:05 – 16:30

Chenrui An

Presentation(s):

• 2 - GENE EDITING: OPTIMIZATION AND APPLICATION IN PRIMARY CELLS

  6/21/2018
  16:05 – 16:30

Ruwanthi Gunawardane

Allen Institute for Cell Science, Washington, United States

Presentation(s):

• Innovation Showcase: PROVIDING STEM CELL & GENE EDITING RESOURCES TO EMPOWER YOUR RESEARCH - Allen Institute for Cell Science

  6/21/2018
  11:30 – 12:30

• 3 - ENDOGENOUS GENE TAGGING WITH CRISPR/CAS9 TO ILLUMINATE CELL ORGANIZATION AND DYNAMICS

  6/21/2018
  16:30 – 16:45

Markus Grompe

Oregon Health & Science University, OR, United States

Presentation(s):

• 4 - SELF-CLEAVING GUIDE RNAS FOR SELECTIVE EXPANSION OF PRECISELY GENE EDITED HEPATOCYTES IN VIVO

  6/21/2018
  16:45 – 17:00

• A UNIVERSAL SYSTEM FOR PHARMACOLOGICAL SELECTION OF GENE EDITED HEPATOCYTES

  6/28/2019
  09:20 – 09:40

Haibo Zhou

Institute of Neuroscience, China

Presentation(s):

• 5 - IN VIVO SIMULTANEOUS TRANSCRIPTIONAL ACTIVATION OF MULTIPLE GENES IN THE BRAIN USING CRISPR–DCAS9-ACTIVATOR TRANSGENIC MICE

  6/21/2018
  17:00 – 17:15

Rodica Stan

City of Hope, CA, United States

Presentation(s):

• 6 - FIRST-IN-HUMAN STUDY OF FEASIBILITY, SAFETY AND ENGRAFTMENT OF ZINC FINGER NUCLEASE CCR5-MODIFIED CD34+ HEMATOPOIETIC STEM/PROGENITOR CELLS IN HIV-1 (R5) INFECTED SUBJECTS

  6/21/2018
  17:15 – 17:30

Danwei Huangfu

Memorial Sloan Kettering Cancer Center, NY, United States

Danwei Huangfu is an Associate Professor in the Developmental Biology Program at Sloan Kettering Institute of Memorial Sloan Kettering Cancer Center. The Huangfu lab is interested in embryonic development and stem cell biology. The lab applies precision genetics in human pluripotent stem cells (hPSCs), including both embryonic and induced pluripotent stem cells, to understand both conserved and non-conserved aspects of human development and disease mechanisms. In particular, the lab has focused on studying diseases that affect the pancreas, including diabetes and pancreatic cancer; and the regulation of DNA methylation during hPSC self-renewal and differentiation. More information about her research can be found from http://www.mskcc.org/huangfu.

Presentation(s):

• 7 - HUMAN DEVELOPMENT AND DISEASE THROUGH THE LENS OF PLURIPOTENT STEM CELLS

  6/21/2018
  17:30 – 17:55