Marianne E. Bronner
California Institute of Technology, CA, United States
Marianne Bronner has a long-standing interest in specification, migration and differentiation of neural crest stem cells. Her early work pioneered the use of a single cell lineage labeling approach for analyzing the developmental potential of neural crest cells in vivo to show that premigratory and migrating neural crest cells are multipotent. She went on to define several of the signals underlying their induction (e.g. Wnt) and segmental migration (e.g. neuropilin/Sema and Eph/ephrin). More recently, her lab has systematically exploited this knowledge together with systems level transcriptional profiling, phylogenomic analysis and in vivo functional perturbation experiments to reveal direct connections in the gene regulatory network responsible for neural crest formation and evolutionary origin.
16:00 – 16:05