Nick Barker

Institute of Medical Biology, Singapore

As a postdoc with Hans Clevers, Nick identified deregulation of the Wnt signalling pathway as a major initiating event in colon cancer and subsequently joined Semaia Pharmaceuticals in 2001 to develop small molecule inhibitors of the Wnt pathway as colon cancer therapeutics. In 2006, he rejoined Hans Clevers group, where he identified the Wnt target gene Lgr5 as a marker of adult stem cell populations in various organs. In 2010, Nick joined the IMB in Singapore, where he focuses on the role of Lgr5 gastric stem cells in self-renewal and cancer.

Presentation(s):

• 1 - TOPIC OVERVIEW BY CHAIR

  6/21/2018
  13:15 – 13:20

• 3 - LGR5+ STEM CELLS IN EPITHELIAL MAINTENANCE, REPAIR AND CANCER OF THE MOUSE STOMACH

  6/23/2018
  09:50 – 10:15

• Navigating Scientific Career Paths in Academia and Industry

  6/23/2018
  11:30 – 13:00

Valerie Horsley

Yale University, CT, United States

Valerie Horsley received her B.S. from Furman University and was awarded her Ph.D. from Emory University in 2003. Her postdoctoral work with Elaine Fuchs at Rockefeller University explored intrinsic factors in epithelial stem cells that control tissue regeneration. In 2009, she began her laboratory at Yale University in the Department of Molecular, Cellular and Developmental Biology. Her laboratory studies tissue regeneration, using epithelial tissues as a model system. Her innovative work focuses on how stromal cells such as adipocytes and immune cells interact to regulate tissue regeneration. Dr. Horsley has received numerous honors including a Pew Scholar award and Presidential Early Career Award from Obama. Dr. Horsley also spends time with her two daughters and is currently a candidate for CT State Senate.

Presentation(s):

• 2 - LET'S TALK ABOUT STROMA: ADIPOCYTES AND FIBROBLASTS IN TISSUE REGENERATION AND REMODELING

  6/21/2018
  13:20 – 13:45

Brett Shook

Presentation(s):

• 2 - LET'S TALK ABOUT STROMA: ADIPOCYTES AND FIBROBLASTS IN TISSUE REGENERATION AND REMODELING

  6/21/2018
  13:20 – 13:45

Rachel Zwick

Presentation(s):

• 2 - LET'S TALK ABOUT STROMA: ADIPOCYTES AND FIBROBLASTS IN TISSUE REGENERATION AND REMODELING

  6/21/2018
  13:20 – 13:45

Ya-Chieh Hsu

Harvard University Department of Stem Cell and Regenerative Biology, MA, United States

Presentation(s):

• 3 - BEYOND GOOSEBUMPS: INTERACTIONS BETWEEN THE HAIR FOLLICLE, THE ARRECTOR PILI MUSCLE, AND THE SYMPATHETIC NERVE DURING DEVELOPMENT AND HAIR FOLLICLE REGENERATION

  6/21/2018
  13:45 – 14:00

Kif Liakath-Ali

King's College London, United Kingdom

Presentation(s):

• 4 - AN EVOLUTIONARILY CONSERVED RIBOSOME-RESCUE PATHWAY MAINTAINS MOUSE EPIDERMAL STEM CELL HOMEOSTASIS

  6/21/2018
  14:00 – 14:15

Thierry Jarde

Monash University, VIC, Australia

Presentation(s):

• 5 - ACTIVATION OF NEUREGULIN1/ERBB SIGNALLING PROMOTES INTESTINAL STEM CELL PROLIFERATION AND IMPROVES TISSUE REGENERATION FOLLOWING DAMAGE

  6/21/2018
  14:15 – 14:30

Arshad Ayyaz

Lunenfeld-Tanenbaum Research Institute, ON, Canada

Presentation(s):

• 6 - ELUCIDATING THE RADIATION RESISTANCE MECHANISMS IN THE REGENERATIVE MOUSE INTESTINE USING SINGLE CELL RNA SEQUENCING

  6/21/2018
  14:30 – 14:45

Sara Wickström

Max Planck Institute for Biology of Ageing, Germany

Sara Wickström studied medicine at the University of Helsinki, Finland, receiving her MD in 2001 and PhD in 2004. After postdoctoral training with Reinhard Fässler at the Max Planck Institute for Biochemistry in Munich, Germany, she was appointed as Group Leader at the Max Planck Institute for Biology of Ageing in Cologne, Germany in 2010. In 2018 her laboratory moved to the newly founded Helsinki Institute for Life Science at the University of Helsinki, Finland. Research in the Wickström lab aims to establish quantitative principles of epidermal stem cell niche self-organization, and how mechanical forces and cellular interactions integrate single cell behaviors to generate and maintain global patterns of a multicellular tissue.

Presentation(s):

• 7 - REGULATION OF EPIDERMAL STEM CELL FATE BY NICHE-DERIVED SIGNALS AND FORCES

  6/21/2018
  14:45 – 15:10

• 1 - TOPIC OVERVIEW BY CHAIR

  6/23/2018
  13:15 – 13:20