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Tuesday, June 19, 2018
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Allergy/asthma
T.7
T.7 - A novel role of human lung endothelial cells in allergic airway disease by producing and responding to IL-33
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T.22
T.22 - A role for early oral exposure to house dust mite proteases in food allergy susceptibility
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F.115
F.115 - Airway epithelium from asthmatic patients have altered immune responses to human rhinovirus infection
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F.99
F.99 - Duration of attenuation of allergic responses after modulation of idiotypic regulatory network
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W.89
W.89 - Elevated Local and Systemic Allergen-specific IgA Following Timothy Grass Sublingual Immunotherapy
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F.53
F.53 - IL-10 producing lung resident memory TR1-like cells do not protect against allergic airway inflammation
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W.40
W.40 - Local Immunoglobulin E Production in Colorectal Polyps of Patients with Food Allergy
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T.20
T.20 - NHERF1 mediates the pathogenesis of airway inflammation in a murine model of house dust mite-induced asthma
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F.35
F.35 - Physicochemical Characterization of Philippine Grass Flora for Diagnosis of Respiratory Allergies
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W.113
W.113 - Progressive increase in allergen concentration abrogates immune tolerance in ovalbumin-induced murine model of chronic asthma
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T.21
T.21 - The Effect of Fenretinide on Regulatory B Cell Development and Semaphorin 4C in Allergic Asthma Model
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Autoimmune neurologic diseases
T.57
T.57 - A molecular characterization of meningeal inflammatory infiltrates in the progressive multiple sclerosis brain
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T.6
T.6 - A novel self-regulatory mechanism of Th17 cells controls autoimmune uveitis through interleukin-24
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W.69
W.69 - Abatacept Selectively Modulates CD4+ Treg, Tfh, and CD38-expressing T cells in the Periphery of Patients with Relapsing-Remitting Multiple Sclerosis
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F.88
F.88 - Acute and Chronic Damage by Autoantibodies in a Model of Neuropsychiatric Systemic Lupus Erythematosus
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T.81
T.81 - Cbl-b deficiency in the myeloid cell lineages but not T cells is responsible heightened Th17 response
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W.9
W.9 - Detection and Characterization of Novel Myelin-reactive CD8+ T cell Populations in Multiple Sclerosis
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F.56
F.56 - Dysregulation of peripheral lymphocytes in Myalgic encephalomyelitis/Chronic Fatigue Syndrome
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W.46
W.46 - Exosomal let-7i inhibits the differentiation of regulatory T cells in multiple sclerosis
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T.97
T.97 - Fingolimod Modulates T Cell Phenotype and Regulatory T Cell Plasticity in vivo
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F.19
F.19 - From T Cell Receptor to antigen, systems approach to discovering T cell antigen(s) in Multiple sclerosis and Experimental autoimmune encephalomyelitis
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W.110
W.110 - Immunoglobulin A is a critical regulator of demyelinating neuroinflammation
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T.16
T.16 - Immunological Dysregulation in Neuromyelitis Optica and its Recovery Following Anti-IL-6 Receptor Monoclonal Antibody Tocilizumab Treatment
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F.17
F.17 - Increases in Eomes-expressing Th cells in secondary progressive multiple sclerosis reveal patients at risk of increased disability
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F.94
F.94 - Induction of Self-Tolerance in Chronic Experimental Autoimmune Encephalomyelitis Using Mixed Chimerism and Allogeneic Neural Stem Cell Transplantation
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W.73
W.73 - iNKT cell ligand OCH induces anti-inflammatory immune responses in patients with multiple sclerosis: Results of investigator-initiated, first-in-human phase 1 study
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W.54
W.54 - Mass Cytometry assisted phenotyping identified structural rewiring of immune system in refractory epilepsy
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F.75
F.75 - Myelin-Specific CD8+ T cells Recruited to the Central Nervous System During CD4+ T Cell-Induced Autoimmunity Exacerbate Brain but not Spinal Cord Disease
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W.82
W.82 - Ocrelizumab does not modulate peripheral T cell functionality or prevalence in a small subset of relapsing MS patients enrolled in OPERA I, a phase III double-blind doubledummy interferon beta-1a-controlled study
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F.29
F.29 - Recirculating Intestinal IgA-producing cells Regulate Neuroinflammation during EAE in mice
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T.31
T.31 - Schwann cell-derived periostin promotes autoimmune peripheral polyneuropathy via macrophage recruitment
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W.4
W.4 - Subsets of micro-RNAs may serve as novel biomarkers and therapeutic targets in multiple sclerosis
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W.5
W.5 - The expression signature of very long non-coding RNA in myalgic encephalomyelitis / chronic fatigue syndrome
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T.67
T.67 - TIGIT Regulates CD4 Autoreactive T cells in Multiple Sclerosis
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F.119
F.119 - TOLERance Induction with Autologous Tolerogenic Dendritic Cells Treated with VITamin D3 and Loaded with Myelin Peptides in Multiple Sclerosis (TOLERVIT-MS trial): The Design of a Multicenter, Dose-Escalation Phase I Clinical Trial
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Autoimmune rheumatologic diseases
T.40
T.40 - A Natural Killer cell based disease activity score for Rheumatoid arthritis patients: Novel mathematical intervention in rheumatic disease biology
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W.60
W.60 - A Novel “Anti-Vaccine” for the Treatment of Collagen-Induced Arthritis
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F.78
F.78 - A protective langerhans cell-keratinocyte axis is dysfunctional in lupus photosensitivity
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W.105
W.105 - Autoantibody profile and clinical significance in Idiopathic Inflammatory Myositis
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F.100
F.100 - BAFF promotes progressive lupus nephritis via activation of the B cell surface receptor TACI.
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F.58
F.58 - Characterization of a novel epigenetic regulator required for T helper 17 differentiation
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F.38
F.38 - Computational Analysis of Clinical Data in a Well-Phenotyped Lupus Cohort Points to Disease Subtypes
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F.74
F.74 - Dermal lymphatic function and photosensitivity in a lupus model
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T.29
T.29 - Development of citrullinated-vimentin-specific CAR for targeting Tregs to treat autoimmune rheumatoid arthritis
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T.44
T.44 - Dysregulation of Innate, Adaptive and TNF-Superfamily Immune Pathways Alongside Autoantibody Accrual Informs a Biological Surrogate for Clinical Disease Activity in Lupus
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T.61
T.61 - Elevated Neopterin Levels are Associated with Dyslipidemia in Juvenile Dermatomyositis
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T.87
T.87 - Enhancers in Autoimmune Disease Cells Contribute to Disease Pathogenesis
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W.47
W.47 - Enrichment of RORγt+ Innate-like T Cells in Intestinal Biopsies from Spondyloarthritis Patients
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W.93
W.93 - Evaluation of the LIA-ANA-Profile-17S for the detection of autoantibodies to nuclear antigens
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F.52
F.52 - Extracellular vesicles in systemic juvenile idiopathic arthritis
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W.20
W.20 - Gene Expression Analysis Delineates the Roles of Multiple Type 1 Interferons in Systemic Lupus Erythematosus
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F.43
F.43 - Gene Expression Analysis Reveals Different Ancestry Related Cellular Contributions to Systemic Lupus Erythematosus (SLE)
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T.37
T.37 - High dimensional analysis of immunome in systemic sclerosis reveals abnormalities in frequency and function of MAIT cells
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W.31
W.31 - Identification of a novel B cell subset in Systemic Lupus Erythematosus using AMNIS Imaging Flow Cytometry
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F.89
F.89 - Immune Cells Avoid Death from Immunoproteasome Inhibitors by Switching to Conventional Proteasome
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T.46
T.46 - Immune Cells From Sisters Of Lupus Patients Highlight Important Pre-disease Epigenetic States And The Factors That Induce Them
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F.44
F.44 - Integration of BCR, TLR, BAFF Receptor and TACI Signals Promotes Autoantibody Production by Transitional B Cells in BAFF Transgenic Mice
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T.68
T.68 - Integrative Analysis of Clinical and Molecular Data on a Well-Phenotyped Lupus Cohort Identifies Molecular Associations with Disease Manifestations
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W.55
W.55 - Kidney Infiltrating T cells in Murine Lupus Nephritis are Metabolically and Functionally Exhausted
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W.48
W.48 - Low density granulocytes and Neutrophil Extracellular Traps as key players of disease activity in patients with idiopathic inflammatory myopathies
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W.75
W.75 - Manipulation of Immune Checkpoints via an Epitope-Specific Vaccine Restores Immune Tolerance and Induces Clinical Amelioration in Human Rheumatoid Arthritis.
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T.35
T.35 - MicroRNAs as novel biomarkers of disease development and therapeutic response in autoimmune arthritis
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T.54
T.54 - Molecular mechanisms of autophagic memory in pathogenic T cells in human arthritis.
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F.5
F.5 - Multi-cohort transcriptome analysis implicates novel biological mechanisms in active systemic lupus erythematosus
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F.16
F.16 - New Insights in the Pathogenesis of Immune-Mediated Necrotizing Myopathies: Role of Auto-Antibodies and Complement in vitro and in vivo
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W.42
W.42 - Novel innate and adaptive immunity abnormalities as key risk factors for infections in patients with systemic lupus erythematosus: Results from the GERMEN cohort
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W.52
W.52 - Pathological Consequences of Anti-PAD4 Antibody Binding to the Surface of Monocytes: Implications in Rheumatoid Arthritis
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F.7
F.7 - Persistence of Transcriptomic Signature in CD4 Memory T Cells in Polyarticular JIA Patients despite Anti-TNFA Biologics Therapy
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T.48
T.48 - Prolactin and autophagy in Systemic Lupus Erythematosus: Clinical significance of correlation between PRL-Receptor and Atg14+ expression on B and T reg Cells.
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F.28
F.28 - Selective inhibition of NF-kB inducing kinase (NIK) is therapeutically efficacious in IFN-accelerated lupus nephritis prone mice
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T.86
T.86 - Specialization of Vascular Adventitial Fibroblasts Correlates with Lymphocyte Infiltration in Human Dermal Diseases
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T.73
T.73 - The SLE-associated Gene BANK1 Inhibits Macroautophagy and Restricts Plasma Cell Differentiation and Immunoglobulin Production by Human B Cells
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F.65
F.65 - The transcriptional co-activator BOB.1 inhibits plasma cell differentiation and induces costimulatory capacity of B cells in GC-like environment
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W.111
W.111 - Using metabolomics to understand the immunopathogenesis of juvenile-onset SLE and stratify patient groups
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T.69
T.69 - Vitamin D reduces the Th17-phenotype in ACT1/Act1-associated Systemic Lupus Erythematosus
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Bone marrow or stem cell transplantation
W.85
W.85 - Autologous iPSC-derived Thymic Epithelial Cells as Cell Therapy to Restore Thymic Function in Stem Cell Transplant Recipients
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W.90
W.90 - Biomaterial Substrate-Mediated Three-Dimensional Culture Enhance the Immunosuppressive Action of Mesenchymal Stem Cells on Inflamed Immune Cells In Vitro and In Vivo
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W.32
W.32 - Expression of Programmed cell death protein-1 (PD-1) on T cells after Allogeneic Hematopoietic Stem Cell Transplantation
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F.107
F.107 - Fate of Endothelial progenitor cells in an altered intracellular and mitochondrial calcium homeostasis
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T.114
T.114 - Impact of HLA disparity in the UCB transplant outcome of malignant and non-malignant diseases
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F.3
F.3 - iR-HLA cassette: An automated and integrated solution for NGS based HLA-typing
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F.11
F.11 - MicroRNA-23a Plays an Essential Role in Graft-versus-Host Disease
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T.47
T.47 - Scatterbodies for Morphometric Profiling by Single Cell Mass Cytometry in Human Hematopoietic Cells
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W.115
W.115 - TIM-1 in the donor graft modulates graft-versus-host disease following allogeneic hematopoietic cell transplantation
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Cytokines/chemokines
W.109
W.109 - An aberrant SPDEF-CCL2 molecular mechanism promotes metastasis of prostate cancer
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F.117
F.117 - Epigenetic editing of FOXP3 in human T cells induces overexpression and is sufficient to create a regulatory T cell phenotype in vitro.
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T.70
T.70 - ILC2s and Type 2 Immunity Influences Hair Follicle Stem Cell Proliferation and Skin Homeostasis
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W.27
W.27 - Investigating the expression, function and regulation of IL-17A and IL-17F expressing CD4+ T cells in human health and inflammatory disease
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F.62
F.62 - Is Depression a Consequence of Immunological Changes among Heavy Users of Alcohol?
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F.69
F.69 - Progression from NAFLD to NASH: Miscommunication between the intestinal microbiota and the CD4 T-cells as a potential cause
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T.118
T.118 - Quantitative Bead-Based Multiplex Immunoassays for Human Bone Metabolism
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W.100
W.100 - Targeting IL-17-producing T cells attenuates the severity of Pseudomonas aeruginosa lung infection
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T.13
T.13 - Toxoplasma gondii Induces IL-1β Production and Pyroptosis Independent Release from Primary Human Monocytes through the Syk Signaling Pathway
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Diabetes and other autoimmune endocrine diseases
F.47
F.47 - A Novel Mendelian Model of Autoimmune Diabetes
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T.19
T.19 - A Single Dose of Siltuximab can Transiently Modify T-effector Resistance to Suppression in T1D
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F.2
F.2 - Aire-dependent thymic FoxP3+ regulatory T cells in Type 1 Diabetes
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T.79
T.79 - Autologous Activation of Diabetogenic CD3+ T Cells in an In Vitro Model of Type 1 Diabetes
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F.63
F.63 - Circulating CXCR5-PD1hi Peripheral T Helper Cells are Increased in Children with T1D and in Autoantibody-Positive Children At-risk for T1D
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T.49
T.49 - Combined Features of T and B Cells Define Distinct Immunotypes of Adult T1D Subjects
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T.30
T.30 - Discovery of a novel human anti-IL-2 antibody that potentiates Regulatory T cells by a structure-based mechanism
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F.67
F.67 - Follicular regulatory T cells expand in the peripheral blood of patients with type 1 diabetes and express reduced levels of PD-1 in the pancreatic lymph nodes
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W.1
W.1 - Glucokinase is Recognized as an Autoantigen in Subjects with Type 1 Diabetes
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W.2
W.2 - HLA-dependent association of systemic antibody responses to intestinal commensal bacteria with islet autoimmunity in pediatric cohorts
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F.54
F.54 - Hyaluronan Levels are Increased in Serum and Muscle of Human Subjects with Type 2 but not Type 1 Diabetes Independently of Glycemic Control
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F.84
F.84 - Hypo-responsiveness is the dominant phenotype of memory T cells following Alefacept treatment of new onset T1D.
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T.28
T.28 - Immune Checkpoint Inhibitor Diabetes Mellitus: An Atypical Presentation of Type 1 Diabetes Mellitus?
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W.8
W.8 - Islet Antigen-Specific CD8 T Cells Within Individual Type 1 Diabetes Subjects Exhibit Multiple Distinct Phenotypes Which Include Features of Both Early Differentiation and Exhaustion
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F.71
F.71 - KLRG1+TIGIT+ CD8 T Cells are a Hyporesponsive Cell Type Varying in Quantity across Individuals and Disease Conditions
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F.114
F.114 - Major impact of 'aging' of adaptive immunity on high-fat diet-induced insulin resistance and nonalcoholic steatohepatitis
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T.83
T.83 - Modulation of cytokine production by dietary fatty acids in T cells from Type 1 Diabetes-susceptible NOD mice
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W.37
W.37 - PD-1 and PD-L1 expression in Graves’ disease’s thyroid glands. A clue to better understand the pathogenesis and immune checkpoint immunotherapy-associated thyroid autoimmunity
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F.34
F.34 - Peripheral Blood Gene Expression Profiling to Identify Biomarkers of Disease Susceptibility in Type 1 Diabetes
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T.77
T.77 - Pro-inflammatory tissue-resident fibroblastic reticular cells promote destructive immune responses in type 1 diabetes.
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F.113
F.113 - Reversal of autoimmune diabetes and restoration of self-tolerance via a cell-based therapy in NOD mouse model
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W.6
W.6 - Single-cell RNAseq Identifies Expanded Clones and Specific Characteristics of Islet Antigen-Reactive Memory T Cells in Peripheral Blood of T1D
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W.83
W.83 - Sustained Delivery of IL-2 Using an Injectable Hydrogel Prevents Autoimmune Diabetes
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W.41
W.41 - Targeting Chronic Inflammation in Ageing and in Type 2 Diabetes Patients using Metformin
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W.16
W.16 - The leader region of preproinsulin contains common epitopes for islet-infiltrating CD8 T-cells derived from organ donors with type 1 diabetes
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General autoimmunity
W.87
W.87 - Brugia malayi recombinant Cystatin ameliorates development of murine Colitis by induction of IL-10+ T-regulatory cells and IL-10+ B1-cells
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F.81
F.81 - Characterization of extra-thymic AIRE-expressing cells using single-cell RNA sequencing
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F.57
F.57 - Different cell types contribute to unique components of the interferon signature in SLE PBMCs
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F.92
F.92 - Dissecting human regulatory T cell signaling using chimeric antigen receptors
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W.35
W.35 - Dynamic Functional Phenotypes of B- and T helper-cells from Autoantibody-positive First Degree Relatives Mark Distinct Stages of Type I Diabetes (T1D) Progression
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W.107
W.107 - Editing of effector T cell activation pathways to model Teff resistance
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F.26
F.26 - Elucidating the Function of Mosaic, a Novel Gene Mediating Autoimmunity
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T.75
T.75 - Foxp3 Domain-Swap Interface is Required to Suppress T Helper Type 2 Transcriptional Program in Regulatory T cells
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W.62
W.62 - Genetically Engineered Tolerogenic Dendritic Cells for Antigen-specific Immunotherapy
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W.49
W.49 - How pro-inflammatory markers and molecular mediators may contibute to immune failure and autoimmunity in aging
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T.39
T.39 - Immunological characterization of IgA Nephropathy patients
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W.61
W.61 - Low-dose Interleukin-2 Expands and Increase Responsiveness of Circulating Regulatory T Cells in Patients with Autoimmune Hepatitis
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T.82
T.82 - Mice Lacking αvβ6- and αvβ8-integrin Activity Display Impaired Thymic Epithelial Cell Maturation
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W.38
W.38 - Modeling the thymic selection of human autoreactive T cells in vivo
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W.67
W.67 - Regulatory Dendritic Cell-Based Strategies for the Development of Innovative Therapies for Celiac Disease
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F.79
F.79 - Regulatory T cells mediate the selection of peripheral naïve B cells
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T.64
T.64 - Role of native mouse thymus and lymphopenia-driven expansion in the development of an autoimmune-like syndrome in humanized mice
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W.11
W.11 - Serum Antibody Specificities in Healthy Infants Reveals a Significant Autoreactive Profile
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T.59
T.59 - Simplified protocol for enrichment of primed human Th17 and Tc17 lymphocytes from peripheral blood.
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T.90
T.90 - The IL-6 receptor alpha chain is essential for the biological function of IL-6
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F.61
F.61 - The role of thymic tolerance in the pathogenesis of the COPA syndrome
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W.19
W.19 - Understanding Immune System Sex Differences in the Healthy Human Transcriptome
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W.39
W.39 - VISTA.COMP is an engineered checkpoint receptor agonist that suppresses T-cell mediated immune responses.
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Genetics
W.21
W.21 - Exploration of SCAMP5 as a Novel Lupus Risk Gene
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F.1
F.1 - Gene editing in primary human T cells to assess autoimmune associated SNPs within the gene PTPN22
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W.17
W.17 - Gene Expression Profile of Tolerogenic Dendritic Cells Differentiated with Vitamin D3, Dexamethasone and Rapamycin
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T.52
T.52 - Human Sinonasal Immunoglobulin D Gene Mutations and Clonal Compartmentalization
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W.23
W.23 - Impact of genetic polymorphisms on human immune cell gene expression
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W.71
W.71 - iReceptor: A Platform for Querying and Analyzing Antibody/B-cell and T-cell Receptor Repertoire Data across Federated Repositories
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T.116
T.116 - PBMC Fixation and Processing for Chromium Single-Cell RNA Sequencing
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F.45
F.45 - RASGRP3 Intronic Variants Affect its Expression, and a Possible Mechanism That Might Contribute to Lupus Risk
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Immune monitoring
W.74
W.74 - A new, positive control peptide pool with broad infectious antigen and MHC coverage that may be useful for assessing anti-infectious T-cell responsiveness
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T.115
T.115 - All-in-One, Quantitative Immune Repertoire Profiling from Challenging Samples
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T.100
T.100 - Analysis of Infiltrating B Cell Populations in the Tumor Microenvironment Using Single Cell Transcriptomics
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T.94
T.94 - Anti-TNF Therapy in Spondyloarthritis: Prediction of Therapeutic Responses Using Immunological Signatures
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W.12
W.12 - Deep Immunology Model Learns Healthy Patient Status from Cytometry Fingerprint
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F.37
F.37 - Development of 12+ color modular staining panels with a common backbone to interrogate CD40L-based activation of human B cells, PBMC, neutrophils and monocyte-derived dendritic cells
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T.33
T.33 - Differential expression CD16 epitopes recognized by clones 3G8 and B73.1 on resting and activated Natural Killer cells.
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W.65
W.65 - Dried Cells as Controls or Standards
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F.118
F.118 - Flow cytometry: identifying biomarkers for the diagnosis of organ-specific autoimmune diseases and response to treatment
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W.70
W.70 - High prevalence of S. pyogenes Cas9-specific T cell sensitization within the adult human population – A balanced effector/regulatory T cell response
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T.99
T.99 - Immune Monitoring of CD34+ Stem Cell Derived Natural Killer Cell Therapy (PNK-007) In A Phase I Study of Acute Myeloid Leukemia
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F.33
F.33 - MHC class II Dextramers - A new tool for detection of antigen specific CD4+ T-cells
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T.41
T.41 - Peripheral lymphocyte subpopulations at onset of type 1 diabetes: imbalance of naïve and memory T cells
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W.3
W.3 - Robust prediction of clinical outcomes using cytometry data
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F.60
F.60 - The CD43-Mediated Signals Differentially Regulate CD4 And CD8 T Lymphocytes Function
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W.92
W.92 - TotalSeq™ , Standardized oligonucleotide barcode antibody conjugates, and Veri-Cells™ PBMC for multiplex immunophenotyping by single cell sequencing
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F.39
F.39 - Using Indocyanine Green Dye to Image Immune Cells in the Human Retina during Ocular Disease
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Immunity & infection
W.66
W.66 - Absence of Sprouty 1 and 2 Enhances CD8+ T Cell Memory Development and Function
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F.85
F.85 - Adjuvant treatment with a dialyzable leukocytes extract contributes to maintain HPV-infected women free of low-grade cervical lesions.
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T.109
T.109 - Akt-2 Is a Potential Therapeutic Target for Disseminated Candidiasis
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F.91
F.91 - Antibodies secretion promoted by a recombinant BCG strain induces a protective immune response against human respiratory viruses
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F.77
F.77 - CD161 Promotes Prenatal Immune Suppression of Human IFNgamma-producing PLZF+ T Cells
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F.106
F.106 - CD8 T cell memory frequency and repertoires to influenza and Epstein Barr virus co-evolve with increasing age from young adult to elderly
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T.110
T.110 - Differential signaling through TLR7 or TLR8 determines the phenotype of human monocytes during RNA viral infection.
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W.104
W.104 - Early Cytokine Signatures Discriminate Persistent from Resolving MRSA Bacteremia
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F.105
F.105 - Effect of 17β-estradiol, Progesterone and Prolactin on the Infective Capacity of Toxoplasma gondii, Cytokine Modulation and the Expression of Hormonal Receptors on THP-1 Cells
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F.103
F.103 - Epigenetic and Transcriptomic Signatures Associated with Antibiotic-Persistent MRSA Bacteremia
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W.99
W.99 - Estrogen Receptor Alpha (ERα) Antagonist Mediates Therapeutic Benefit against Urinary Tract Infection (UTI) by Boosting TNFα Production in Bladder
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T.34
T.34 - Extended Phenotypic Immunome Characterization (EPIC): A Reference Atlas of the Changing Immune Landscape from Birth to Adulthood
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W.101
W.101 - Fcγ-Receptor Binding and Fc-Mediated Antibody Effector Functions in a Human HIV-1 Vaccine Efficacy Trial
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T.111
T.111 - HECT E3 Ubiquitin ligase Nedd4 is required for anti-fungal innate immune response
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F.30
F.30 - Human Memory CD8 T cell Effector Potential is Epigenetically Preserved During In Vivo Homeostasis
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W.97
W.97 - Human Tonsil Cultures as a Model to Study Adaptive Immune Responses In Vitro
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F.102
F.102 - IL-10 production by myeloid cells is essential to keep the lung integrity during infections caused by the major pathogenic bacteria Klebsiella pneumoniae ST258 and Streptococcus pneumoniae.
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F.49
F.49 - Immune Paralysis and Lymphopenia is Associated with Adenosine A1 Receptor Dysfunction
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W.102
W.102 - Immune Response to Influenza Vaccine in Sickle Cell Disease Patients
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F.20
F.20 - Influenza A virus (IAV) infection in humans leads to expansion of highly diverse CD8 T cell repertoires cross-reactive with Epstein Barr virus (EBV)
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W.103
W.103 - Lymphatic Filariasis Infection is reemerging in India emphasizing the need for a Prophylactic Vaccine for mass control
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W.94
W.94 - Macrophages Contribute to Protective Memory in Recurrent Staphylococcus aureus Skin and Invasive Infection
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T.89
T.89 - Mechanosensitivity of Immature Dendritic Cells in Mechanically Tunable Three-Dimensional Matrices
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W.77
W.77 - Molecular mechanisms underlying in vitro-rejuvenation of virus-specific memory T cells
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F.70
F.70 - Molecular profiling of human regulatory T cell subsets supports a linear differentiation model and identifies a novel regulatory T cell population with stem cell-like properties
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W.91
W.91 - Novel adjuvant systems elicit unique and protective cellular and humoral immune responses in Q fever challenge model using a polyvalent C. burnetii vaccine
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W.53
W.53 - Nutrient sensing by CD11c+ cells modulates host microbiome to promote metabolic homeostasis
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W.106
W.106 - Pharmacological Induction of Heme Oxygenase-1 Hinders Herpes Simplex Virus Replication by Interfering With The Nuclear Accumulation of Viral Capsids after Infection
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T.63
T.63 - Phase I clinical trial for a recombinant BCG expressing the nucleoprotein of the human respiratory syncytial virus (hRSV) in healthy adults.
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F.80
F.80 - Pioneering bacteria in fetal meconium drive divergent intestinal T cell development
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W.114
W.114 - Respiratory Syncytial Virus Glycoproteins Activate Primary Human Dendritic Cells
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W.96
W.96 - Riding The Perfect Storm. Severe Rash Resulting From Simultaneous Infection with Influenza B virus, Erythrovirus B19 And Influenza B immunization
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F.18
F.18 - Role of CD1d receptor in the pathology caused by the human Respiratory Syncytial Virus and the human Metapneumovirus
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T.45
T.45 - Seroprevalence of Brucella-specific antibodies in at-risk subjects among rural and suburban communities in different provinces of southern regions of Saudi Arabia
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T.84
T.84 - Serum Level of Soluble Programmed Death Protein-1 as a Predictor of Disease Progression in Patients with Nontuberculous Mycobacterial Lung Disease
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W.28
W.28 - Signal Integration in Immune Regulatory Networks
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W.112
W.112 - Soluble protein biomarkers in late-onset neonatal sepsis: potential value in diagnosis
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F.82
F.82 - Strategy for performing second treponemal tests in reverse-sequence algorithms of syphilis diagnosis
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W.15
W.15 - Th17/regulatory T cells balance is predictive of Coccidioides infection outcome in pediatric patients
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T.55
T.55 - The long chain fatty acid transporter, MFSD2A, is essential for memory CD8+ T cell formation and maintenance
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W.45
W.45 - The NLRP3 inflammasome impairs CD8+ T cell responses in murine viral hepatitis.
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F.13
F.13 - Transcriptional Signatures of Influenza Vaccine Immune Responses in Elderly Individuals
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T.80
T.80 - Tyrosine Phosphorylation of NLRP3 by Src Family Protein Tyrosine Kinase Lyn Suppresses NLRP3 Inflammasome Activation
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Immunodeficiency: primary or acquired
F.22
F.22 - A combined immunodeficiency with severe inflammation and allergy caused by ARPC1B deficiency
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W.18
W.18 - A novel Btk mutation manifesting as late-onset x-linked agammaglobulinemia
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T.53
T.53 - Aberrant Innate-Like Lymphocytes Causing Atopy and Immune Dysregulation in a Patient With a Novel BCL11B Variant Revealed by Mass Cytometry (CyTOF)
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F.68
F.68 - Antibody Profiling Identifies a Strong and Wide Spread Auto-Immune Response in Idiopathic CD4 Lymphopenic Patients
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F.36
F.36 - Flow Cytometry as a Screening Tool of Primary Immunodeficiency Diseases
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F.97
F.97 - Importance of individual titration and monitoring in vitro of ruxolitinib treatment of patients with STAT1 GOF mutations
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T.58
T.58 - Lentiviral-mediated FOXP3 gene transfer to convert CD4+ T cells to Treg cells: a suitable method for immunotherapy
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F.104
F.104 - Mechanisms of Thymic Hypoplasia in Mouse Models of 22q11.2-DiGeorge Syndrome
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T.91
T.91 - Patients with Novel Compound Heterozygous Mutations in Forkhead Box N1 (FOXN1) Have a Severe Immunodeficiency without Alopecia or Nail Dystrophy
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F.83
F.83 - Role of Rho kinases in B cell development
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W.25
W.25 - The mechanisms of immune system dysregulation in Common Variable Immunodeficiency – the role of T helper cells
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F.46
F.46 - The Thymus in the Chromosome 22q11.2 Deletion Syndrome (22q11DS)
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F.12
F.12 - Tumor suppressor BAP1 is essential for thymic development and proliferative responses of T lymphocytes
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T.43
T.43 - Using Transcriptional Profiling to Understand Early Human T Cell Development
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Immuno-dermatology
W.57
W.57 - Assessing a potential role of stem cell memory T cells as cancer-initiating cells in Sézary syndrome
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F.76
F.76 - IgA Nephropathy presenting with Chronic Urticaria
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F.14
F.14 - Immunomodulation and regeneration effect of biosynthetic dressing loaded with silver nanoparticles and TNFa inhibitor in a non-traumatic wounds experimental model
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F.41
F.41 - MIF gene polymorphisms are not a genetic risk factor for NSV susceptibility in a Western Mexican population
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F.48
F.48 - Multidimensional Approaches to Define the Risk and Immunopathogenesis of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Associated with Nevirapine in South Africa
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T.3
T.3 - SEB stimulation induces functional pathogenic features in Th17 cells from psoriasis patients
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T.15
T.15 - Tc17/MAIT cells in Psoriatic Arthritis: Regulatory role of the IL-23 and its receptor system
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T.71
T.71 - Unexpected cutaneous effects in IL31-deficient animals
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Immunology of the eye
T.10
T.10 - A New Model of Autoimmune Retinopathy Demonstrates the Critical Importance of IL-10 to Retinal Protection
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T.4
T.4 - An abnormal mucosal immune response to an ocular surface commensal precipitates inflammation in a model of Muckle-Wells Syndrome
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T.56
T.56 - Association Study between HLA genes and Climatic Droplet Keratopathy (CDK) in a cohort from the Patagonian region of Argentina
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W.24
W.24 - Clinical effect of IRT5 probiotics on dry eyes
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F.55
F.55 - Macrophage Activity and Survival are Regulated by Exosomes from Retinal Pigment Epithelial Cells
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T.65
T.65 - The induction of specific systemic tolerance to encephalitogenic antigens via the ocular route or adoptive transfer of cells
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W.88
W.88 - Therapeutic recovery of retinal pigment epithelial cell suppression of macrophage phagocytic activity by alpha-melanocyte stimulating hormone is not through the melanocortin 5 receptor
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Immuno-oncology
F.86
F.86 - Activation of Endogenous Anergic Self-specific CD8+ T cells by Polymeric Nanoparticles for Enhanced Cancer Immunotherapy
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F.4
F.4 - Augmentation of a Novel Adenoviral Vaccine Strategy By Checkpoint Inhibitors
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F.8
F.8 - Boosting anti-tumor response by conferring cysteine autonomy to T cells
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F.109
F.109 - Chemotherapy Potentiates Immunotherapeutic Efficacy of Recombinant Oncolytic Poliovirus
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W.81
W.81 - Control of lymphocytic leukemia through regulation of TRAF1 protein degradation
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F.6
F.6 - ConvertibleCAR T-Cells Provide Dose Control of Activity and Targeting Flexibility
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T.93
T.93 - Discovery screen platform for co-modulators of T cell effector function against tumors
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T.74
T.74 - Dissecting The Cellular Mechanisms Of Disease Pathology Caused By Gain-Of-Function Mutations In PIK3CD
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F.21
F.21 - Engineering Antigen-Specific T cells from Human Pluripotent Stem Cells
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T.62
T.62 - Epigenetic Reprogramming of Intratumoral Regulatory T cells Enhances Cancer Immunity
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W.14
W.14 - ESCAPE RNA sequencing: combining protein and nucleic acid measurements to profile immune cells
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T.38
T.38 - ESCAPE TCR sequencing: Combining TCR sequencing with protein based cellular phenotyping in immune profiling
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T.117
T.117 - Forcing melanoma cells to be stressed stimulates apoptotic and immunogenic responses
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T.98
T.98 - Genetic Modification Potentiates the Anti-Tumor Activity of Human Cord Blood Progenitor (CD34+) Derived NK Cells
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T.105
T.105 - Improved T Cell Activation Bioassays to Advance the Development of Bispecific Antibodies and Engineered T Cell Immunotherapies
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W.72
W.72 - In vitro generated Tr1 cells eliminate primary pediatric acute myeloid leukemia
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T.5
T.5 - Induction of T-allo10, an alloantigen specific Type 1 regulatory T cell product suitable for cellular therapy in hematopoietic stem cell transplantation for hematologic malignancies
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T.104
T.104 - Measurement of Fc-mediated ADCC and CDC Activity of anti-TNFα and anti-VEGF Therapeutic Antibodies using Reporter-based Bioassays and Engineered TNFα+ and VEGF+ Target Cells
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W.58
W.58 - Mutations of forkhead box P3 and their impact on hepatocellular carcinoma
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W.79
W.79 - NLRP3 inflammasome promotes IL-17-mediated tumor immunity while increasing IDO1 in the tumor microenvironment.
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F.95
F.95 - PD-1 blockade markedly enhances immunity to prostate tumors by adoptively transferred human Vγ2Vδ2 T cells in an NSG mouse model
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T.106
T.106 - Quantitative Cell-Based Bioassays to Advance Immunotherapy Programs Targeting Immune Checkpoint Receptors
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T.107
T.107 - Reproducible MOA-Reflecting Reporter-Based Bioassays to Enable Drug Development of Biosimilars and Biobetters
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T.92
T.92 - Reprogramming human T cell function and TCR specificity with non-viral genome targeting
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T.26
T.26 - Resistance to PD1 blockade in the absence of metalloprotease-mediated LAG3 shedding.
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W.108
W.108 - Single-cell Highly Multiplexed Proteomics Identifies Novel Polyfunctional Human CD8+ T-cell Signatures Induced by a Nanoparticle-Based Melanoma Vaccine in Human Immune System Mice
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F.108
F.108 - Single-cell Polyfunctionality of CD4+ T-cells Shows Promise as a Predictor of Overall Survival of Pancreatic Cancer Patients Treated with GVAX Vaccine
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T.95
T.95 - Skewed CD4 and CD8 T cell differentiation in pancreatic cancer patients
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W.64
W.64 - The interaction of ILT3/LILRB4 receptor with its ligand CD166/ALCAM inhibits tumor cell growth
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F.96
F.96 - Tmem176b is a checkpoint in IL-1β-dependent tumor immunity
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W.76
W.76 - Tumor-resident memory CD8+ T cells are exhausted and less cytotoxic despite epigenetically committed in bladder cancer
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F.23
F.23 - Using Synthetic Biotic™ Medicines to Activate Innate and Adaptive Immunity and Drive Antitumor Immune Response
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Inflammatory bowel diseases
T.36
T.36 - A Novel Whole Blood Assay Detects Flagellin-Specific CD4+ T Cells in Patients with Inflammatory Bowel Disease
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T.25
T.25 - Alpha Kinase 1 Controls Intestinal Inflammation via Suppression of the IL-12/IL-23 Axis
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W.56
W.56 - Analysis of Cecal Immune Response in a Murine Model of Colitis Using Intravital Imaging
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F.111
F.111 - Anti-TNFα Therapy increases Suppressor Regulatory T Cells in patients with Crohn’s Disease
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F.73
F.73 - Building an Immune Single Cell Atlas of Ileum Crohn’s Disease
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W.78
W.78 - Effect of concurrent systemic glucocorticoid use on CSF T lymphocytes in Patients with Moderate-to-Severe Crohn’s Disease
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F.64
F.64 - Effects of Short-term Dietary Changes on Immune System and Beyond
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T.78
T.78 - Mesenchymal Stem Cells have attenuated differentiation and clonogenic potential in Ulcerative Colitis
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F.112
F.112 - Metabolic inhibition of microbiota-reactive CD4 T cells for the prevention and treatment of inflammatory bowel diseases
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F.50
F.50 - Mice Overexpressing MKL1 in Macrophages Are Susceptible to DSS-induced Colitis
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W.84
W.84 - Therapeutic potential of Wuchereria bancrofti derived Macrophage Migration Inhibitory Factor-2 (rWba-MIF-2) in DSS induced colitis mouse model
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Innate immunity
W.33
W.33 - Adhesion and degranulation promoting adaptor protein regulates both direct and indirect anti-tumor responses of invariant natural killer T cells
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F.15
F.15 - An atlas of the mosquito immune system at single-cell resolution
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F.31
F.31 - Caspase-1 Laden Extracellular Vesicles from Cystic Fibrosis Lungs Activate Inflammasome Signalling in Neutrophils and Epithelial Cells
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F.101
F.101 - Diminished B cell response after repeated influenza vaccination
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W.116
W.116 - Glutathione peroxidase 8 negatively regulates caspase-4/11 to protect against colitis by restraining NLRP3-inflammasome activation
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W.63
W.63 - High throughput screening of IRAK4 small molecule inhibitors in TLR ligand stimulated whole blood
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T.76
T.76 - HMGB1 Redox Forms Differentially Mediate Innate-to-Adaptive Immune Switch after Ischemia-Reperfusion Injury in Human Orthotopic Liver Transplantation
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T.103
T.103 - IL-5 signaling in structural or hematopoietic cells protects mice against acute lung injury
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T.2
T.2 - Immune-modulatory role of miR-511-3p on Mannose Receptor Expression and impact on Human DC Function
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W.29
W.29 - Implications of silver nanoparticles on phenotypic changes in murine bone-marrow derived dendritic cells
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W.43
W.43 - Inflammatory phenotypes of monocytes/macrophages in acute CPP arthritis: a comparison with acute gouty arthritis
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W.98
W.98 - Innate Lymphoid Cells are Activated in Acute Dengue Infection and Persist through Clinical Resolution
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T.60
T.60 - Mass Cytometry-Based Analysis of Human Lung Macrophages
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T.108
T.108 - Mycobacterium leprae proteins, GroES and MMP-II, induce extracelullar traps in human neutrophils
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W.13
W.13 - Neutrophils shed tethers that form a new class of elongated shear-derived particles (SDP)
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F.66
F.66 - Opposing roles of CD2 and 2B4 in iNKT cell cytotoxic responses
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F.51
F.51 - Posttranscriptional Control of Microglia-derived Neurotrophic Factors
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T.27
T.27 - Protective Roles of Myeloid SOCS3 to Neuroinflammation in Neurodegenerative Parkinson’s Disease
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T.9
T.9 - Role of SLC7A5 in Metabolic Reprogramming of Human Monocyte/Macrophage Immune Responses
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W.22
W.22 - STING Associated Vasculopathy with onset in Infancy (SAVI) and Chronic Atypical Neutrophilic Dermatosis with Lipodystrophy and Elevated Temperature (CANDLE) are autoinflammatory diseases driven by active type I interferons
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T.85
T.85 - The induction mechanism of Interferon regulatory factor 5 in HMGB1-induced macrophage polarization
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F.27
F.27 - Unique effects of human Tr1 cells on suppressing innate immunity and promoting epithelial health
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Organ transplantation
T.14
T.14 - B cell immune repertoire sequencing identifies pre-transplant rejection risk
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T.17
T.17 - dentification of Transplant Injury Specific Metabolites in the Kidney Transplant Urine By Metabolomics
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T.72
T.72 - Endothelial expression of MHC Class I is necessary for transfusion-related acute lung injury
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W.44
W.44 - Identification of leukocyte subpopulations as potential biomarkers of long-term survival with normal allograft function after lung transplantation
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F.72
F.72 - Phenotypic and Clonal Analysis of Recipient B cells and Plasma Cells Repopulating Graft Mucosa Reveals an Association with Rejection after Human Intestinal Transplantation
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F.59
F.59 - Profile of human alloreactive T cells stimulated by CD40L-stimulated B cells and monocyte-derived dendritic cells
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T.66
T.66 - The preferential expression of donor-HLA molecules by ‘cross-dressed’ cells following clinical liver transplantation is mediated be extracellular vesicles
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W.34
W.34 - Tr1 cell immunotherapy promotes transplant tolerance via de novo Tr1 cell induction and is safe and effective during acute viral infection
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Other - Immunometabolism
T.88
T.88 - Fatty Acid Binding Protein 5 is required for Treg metabolism and function
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Reproductive immunology
W.59
W.59 - Activation and expansion of CD8+ T cells in cord blood and in the maternal-fetal interphase during preterm labor.
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W.26
W.26 - AIRE Supports Maternal-Fetal Tolerance During Early Pregnancy
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T.12
T.12 - Helios drives preferential regulatory T cell differentiation in fetal naïve T cells
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F.40
F.40 - IgA antiphospholipid antibodies: exploring their role in the diagnosis of Antiphospholipid Syndrome in recurrent reproductive failure patients.
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W.51
W.51 - Integrative analysis of miRNA and mRNA sequencing in spontaneous preterm birth
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T.24
T.24 - Meta-Analysis of Maternal and Fetal Transcriptomic Data Elucidates the Role of Adaptive and Innate Immunity in Preterm Birth
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W.7
W.7 - Peripheral Blood Cell MicroRNA predicts Preeclampsia and Preterm Birth when collected Early in the First Trimester of Pregnancy
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T.42
T.42 - Prevalence of Antiphospholipid Antibodies among Groups of Reproductive Failure. Association with Natural Killer Cells and Another Immunological Alterations.
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Therapeutics/pharmacology
T.18
T.18 - A novel inhibitor (N5-1) of interferon regulatory factor 5 (IRF5) ameliorates disease severity in NZB/W F1 mice
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F.93
F.93 - A Synthetic Biology Approach for the Treatment of Cancer and Inflammation
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W.86
W.86 - Addition of anti-CD2 to anti-CD3/CD28-conjugated nanoparticles increases expansion of human CD4+ T cells and IL-10-transduced CD4+ type 1 regulatory T cells
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T.112
T.112 - Antibody-Mediated Protection from an Adenovirus-Vectored RSV Vaccine
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W.68
W.68 - Antisense Spherical Nucleic Acids Targeting IL-1β for Inflammatory Diseases
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T.51
T.51 - Building CRISPR/Cas9-based platforms for therapeutic target identification and validation
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T.101
T.101 - Depletion of Membrane LTα Expressing Cells in Combination with TNFα Neutralization Provides Superior Efficacy in Rheumatoid Arthritis Preclinical Model
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F.90
F.90 - Development of new hollow mesoporous silica nanoparticles coated with mAb Trastuzumab to treat breast carcinoma
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T.11
T.11 - Direct control of inflammation in rheumatoid disorders with tolerogenic nanoparticles
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W.36
W.36 - Exploration of autophagic modulators of Aβ production for inactivating the targeted inflammasomes
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F.98
F.98 - Fostamatinib, a Spleen Tyrosine Kinase (Syk) Inhibitor, for Treatment of Warm Antibody Autoimmune Hemolytic Anemia (wAIHA): Preliminary Results of the SOAR Phase 2, Multicenter, Open-Label Study
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T.96
T.96 - Fostamatinib, an Oral Spleen Tyrosine Kinase (Syk) Inhibitor, in Adult Persistent/Chronic Immune Thrombocytopenia (ITP): Safety and Efficacy Results From Patients Who Converted From Placebo Onto the 049 Open-Label Extension Study
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F.116
F.116 - Gene Therapy Trial for Rare, Severe Neuromuscular Disease: Preliminary Efficacy, Safety and Immunological Findings
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F.10
F.10 - Identification of potent RORc inhibitors for the treatment of IL-17-mediated inflammatory diseases: is it worth the risk?
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F.87
F.87 - In vitro and in vivo pharmacodynamic profile of DV281, a TLR9 agonist, in development as an inhalational therapeutic for lung cancer
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T.1
T.1 - Monocyte NOTCH2 Expression Predicts Interferon-beta Immunogenicity in Multiple Sclerosis Patients
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T.8
T.8 - Repairing Foxp3 mutations in scurfy T cells restores regulatory T cell function
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T.113
T.113 - Retrovirus-derived Virus-Like Particles as tolerogenic vaccines for food allergy treatment
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Transplantation
F.25
F.25 - BPX-501 cell infusion after alpha/beta T-cell and B-cell depleted HLA-haploidentical HSCT (haplo-HSCT) in children with primary immunodeficiencies (PIDs): high rate of cure with low risk of acute and chronic GvHD.
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W.95
W.95 - Clonality and Function Of Cytomegalovirus Specific T Cells In Transplant Recipients
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F.32
F.32 - Complement Induces Inflammasome Assembly in IFN-γ-primed Human Endothelium: Mechanisms and Consequences for Allograft Rejection
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T.50
T.50 - CRISPR/Cas9-Mediated Ablation of Class I and II Major Histocompatibility Complex Antigen Expression on Human Endothelial Cells
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F.24
F.24 - Durable Mixed Hematopoietic Chimerism through Megadose Bone Marrow and Regulatory T cells for the Induction of Immune Tolerance in Non-Human Primates across MHC-barriers
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T.32
T.32 - Ex-vivo expansion of Regulatory T cells from long-term Belatacept-Treated Kidney Transplant Patients restores both their phenotype and in vitro suppressive function
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W.50
W.50 - Generation of human/pig hybrid thymus to achieve immune tolerance to pig antigens with optimal immune function
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F.9
F.9 - HCV-induced heterologous immunity regulates alloreactive T-cell exhaustion in liver transplantation
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W.10
W.10 - Multiplexed Immunofluorescence to Investigate the Immune Response to BK Virus in Kidney Transplant Recipients
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F.110
F.110 - Potential for Immunity and Tolerance after Bilateral Orthotopic Lung Transplant (BOLT) in Tandem with a CD3+/CD19+ Depleted Vertebral Bone Marrow Transplant (BOLT+BMT) from 1 of 8 HLA-Matched Cadaveric Donors
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F.42
F.42 - Precision phenotyping of histologically stable kidney transplants
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T.23
T.23 - Reshaping undesired immune reactivity by regulatory T cells - experience from kidney transplantation (One Study) and chromic GvHD (PegTreg)
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W.80
W.80 - Virus specific T lymphocytes expansion for Adoptive Immunotherapy
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