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Oral health and a quality diet effect health in general, especially in the geriatric population or those with systemic disease. The extraction of diseased teeth and eradication of infectious tissue can transform oral health. Effective replacement of the dentition should strive for achieving masticatory efficiency similar to the natural dentition. In this lecture we will discuss approaches to bone grafting, and full arch restoration of patients indicated for removable or fixed prosthesis. We will describe the technology of coordinated Virtual planning including the perspective of radiology, restorative dentistry, laboratory and surgery. We will introduce anatomically based guided surgery, and guided indexed prosthesis placement. We will discuss prosthetic principles that achieve masticatory efficiency.