Radiation and Cancer Biology

EDU 30 - Targeting Metabolism in Cancer

4:45 PM - 6:15 PM
Location: Room 004

Session Type: Educational
1.50 AMA PRA Category 1 Credits™
1.50 CAMPEP Credits
1.50 MDCB Credits

Since Otto Warburg's description of altered metabolism in cancer over one hundred years ago, significant insights have been made into the multitude of repercussions of the proclivity of cancer cells for glycolysis, even in the presence of oxygen, but recent basic scientific studies have indicated that tumor cells harbor a variety of metabolic differences and dependencies that are potentially therapeutically exploitable. Beyond an increased need for ATP, tumor cells require macromolecule precursors, and maintaining redox balance is increasingly being recognized as an important process in carcinogenesis. This session will highlight recent progress in this rapidly evolving field, including talks focused on novel metabolic targets as well as methodology being utilized to study complex metabolic pathways. This will provide a framework for potential clinical applications, including potential predictive and/or prognostic metabolic alterations as well as monitoring of disease response and/or progression.

Learning Objectives:


Robert Griffin, PhD

University of Arkansas for Medical Sciences: Professor: Employee

IGF Oncology: Stock Options

American College of Cryosurgery: Board Member

Robert J. Griffin, PhD, is a Professor of radiation and cancer biology in the Department of Radiation Oncology at the University of Arkansas for Medical Sciences with over 20 years of experience in peer-reviewed research. Much of his work has been studying the interactions of normal and tumor microvasculature with tumor cells, blood flow, hypoxia and the general role of the tumor microenvironment in driving metabolism and proliferation. Exploiting aspects of the tumor microenvironment to improve response to radiation, thermal treatment, or chemotherapy while maintaining a beneficial therapeutic ratio is the ultimate goal of studies in his research group. He has acted as President and program chair for the Society for Thermal Medicine, which has an emphasis on nanotechnology and radiosensitization using a variety of modalities. He is active on the program committee for the ASTRO refresher course and the Radiation Research society as well as on the annual meeting and scientific and educational program development committee for ASTRO. Currently, he is also associate senior editor for biology for the Red journal as well as radiation therapy section editor for the journal Technology in Cancer Research and Treatment.


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EDU 30 - Targeting Metabolism in Cancer

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