Genetics/Genomics

Abstract

CS-12-3 - Inter-organellar communication and autophagy during innate immunity

Monday, July 16
1:43 PM - 2:03 PM

The innate immune system of both plants and animals employs cell-surface and intracellular receptors to detect pathogens and trigger defenses. Emerging evidence suggests that chloroplasts play an important function during innate immunity and they also have a central role in the production of immune signals. Our recent findings demonstrated that chloroplasts dynamically change their morphology by sending out stroma-filled tubular projections known as stromules during immune responses. I will discuss these findings and our recent results on dynamics of stromule formation and chloroplast association with nuclei during plant innate immunity.


Macroautophagy, hereafter referred to as autophagy, is a dynamic process that is conserved across eukaryotes and entails the engulfment of cellular components or cargoes in double membrane vesicles called autophagosomes. Autophagosomes are then targeted to the vacuole/lysosome for degradation or recycling. It has been well established that recycling of long-lived cellular proteins and organelles by autophagy is an important adaptive response to nutrient deprivation. However, recent studies have revealed that autophagy participates in other diverse biological processes including innate immunity, programmed cell death (PCD), and pathogenesis. I will discuss emerging perspectives on autophagy, cell death, and innate immunity.

Savithramma Dinesh-Kumar, PhD

Professor
University of California, Davis

Dinesh-Kumar is currently a Professor and Chair of Department of Plant Biology and Professor in The Genome Center at University of California Davis. He did his PhD at Iowa State University and postdoctoral research at UC Berkeley and Plant Gene Expression Center. His research program is aimed at understanding the molecular basis of plant immune responses. Crop losses from plant disease exceed several hundred billion dollars annually. These losses are devastating to a global agricultural system already facing the challenges of population growth, water shortages, deep soils, phosphate and other cropping essentials, and changing climate. The main ongoing research areas of his laboratory include: Immune receptor function in pathogen recognition and activation of immune signaling; Role of inter-organellar communications during innate immunity; Role of autophagy in programmed cell death and immunity; CRISPR/Cas9 to engineer virus resistance and genome editing. More information on Dinesh-Kumar laboratory is available at: http://www-plb.ucdavis.edu/labs/dinesh-kumar/


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