Biotic Stress/Applied Plant Bio

Abstract

CS-3-3 - Gating Plant Immunity and Death at the Nuclear Boundary

Sunday, July 15
1:43 PM - 2:03 PM

Effector-triggered immunity (ETI) is a major form of plant innate immunity. Using a combined genetic, genomic and proteomic approach coupled with advanced fluorescence-EM imaging, we discovered a novel transmembrane component of the nuclear pore complex (NPC), CPR5. We found that CPR5 is an immune-responsive NPC structural modular that coordinates permeabilization of the central channel selective barrier during ETI activation and results in simultaneous influx of massive stress-related signaling cargos into the nucleus required for ETI execution. In addition, we found that CPR5-dependent NPC conformational change leads to non-canonical activation of core cell cycle signaling components. Activation of this signaling pathway is essential to drive ETI transcriptional responses, suggesting that conserved cell cycle regulators have evolved important roles in defense activation. Together, this work uncovered a critical gating mechanism for immunity and death at the nuclear pore.


 

Yangnan Gu, PhD

Assistant Professor
Tsinghua University

Dr. Yangnan Gu received his Ph.D. in Molecular Cellular and Developmental Biology from Indiana University Bloomington. He then moved to Duke University-Howard Hughes Medical Institute for his postdoc training with Dr. Xinnian Dong. He is now an Assistant Professor at Tsinghua University in China. Dr. Gu’s study focuses on the molecular mechanism of plant immunity. His recent work discovers a key signaling pathway downstream of the effector-triggered immunity (ETI), one of the most strong and robust plant innate immune responses. He demonstrated that the nuclear pore complex (NPC) is a strategic platform for regulating immune signaling and identified a novel and plant-specific component of the NPC that bridges ETI signaling and immune activation.

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