Education

Abstract

CS-2-6 - Detective: Riding the DNA Subway Red Line From Genotype to Phenotype.

Sunday, July 15
2:43 PM - 2:45 PM

DNA Detective is a workshop designed to introduce 6-12 grade students to computational biology and bioinformatics using Cyverse’s DNA Subway platform. DNA Subway is a user-friendly workspace for genome analysis and uses the metaphor of a network of subway lines to familiarize users with the bioinformatics steps involved in annotating and comparing DNA sequences. For DNA Detective, the DNA Subway Red Line was used to guide students through analyzing a “mystery” DNA sequence, distinguishing its gene structure / function, and identifying the phenotype of its mutant. Students were divided into groups, and each group was assigned a unique Arabidopsis thaliana DNA sequence. Students then “traveled” the Red Line to find and remove sequence repeats, use gene prediction software to structurally annotate their sequence, and search databases of known genes to assign functional annotations to their gene model. Once completed, mutant plants for each Arabidopsis gene were placed in the front of the room, and students were asked to select the mutant defective for their gene. DNA Detective has been presented at two Tech Savvy events, daylong conferences aimed at attracting middle school girls to STEM fields. Through these workshops, students were acquainted to the flow of genetic information from genotype to phenotype and tackled complex genomic analyses in hopes of inspiring and empowering them towards continued STEM education.


 

Co-Authors

Sarah Wyatt – Ohio University

Anne Sternberger

Anne Sternberger
Ohio University

Presentation(s):

Send Email for Anne Sternberger


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CS-2-6 - Detective: Riding the DNA Subway Red Line From Genotype to Phenotype.



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