Category: Federal Forum Posters
Purpose: The primary objective of this study is to evaluate the impact of a clinical pharmacist-driven Staphylococcus aureus bacteremia (SAB) initiative on the receipt of appropriate antibiotics and SAB bundle compliance (including infectious disease consultation obtained, repeat blood cultures obtained, echocardiography obtained, and planned treatment duration of two to six weeks). Secondary objectives include quantification of the impact of this initiative on patient outcomes, such as in-hospital mortality, length of hospital stay, critical care unit length of stay, admission to critical care unit, time (hours) to defervescence, as well as compliance with each component of the SAB bundle.
Methods: This is a retrospective cohort study of patients treated at a community hospital with blood cultures that resulted positive for S. aureus between April 1st, 2012 through March 31st, 2015 (pre-implementation group) versus patients with positive blood cultures for S. aureus between April 1st, 2015 through March 31st, 2018 (post-SAB implementation group). Patients will be excluded from this study if, at the time of the resulting blood culture, they were less than 18 years of age, imprisoned, pregnant or actively nursing, unable to maintain intravenous access, expired before blood cultures resulted, electing not to undergo aggressive care (i.e. hospice or end of life comfort care), or had a documented life-threatening allergy to an agent in the beta-lactam, glycopeptide, oxazolidinedione, or lipopeptide classes of antibiotics requiring selection of an alternative, less optimal agent. We expect approximately four-hundred patients to be included in our study. Each cohort will contain approximately 200 patients. The statistical methods of our investigation will include a chi-squared test or Fisher’s exact test for categorical variables, and a student’s t test or Wilcoxon rank-sum for continuous variables, as appropriate. This study has been submitted for approval by an institutional review board (IRB) committee.
Results: not applicable
Conclusion: not applicable
Andrew Globke– Clinical Pharmacist Resident, Williamson Medical Center, Franklin, TN