Category: Federal Forum Posters
Purpose: In January 2016, insulin 70/30 pens were added to formulary. Published studies have shown benefit in glycemic control and medication adherence in patients transitioned from insulin vials to pens. However, no data were reported for American Indian/Alaskan Native populations. Per CDC, Native Americans have the highest prevalence of diabetes, and there is a need for outcomes data within this population to assess clinical benefit. The purpose of this study is to evaluate the differences in glycemic control and medication adherence in patients transitioned from insulin 70/30 vials to 70/30 pens.
Methods: This retrospective, chart review analyzes glycemic control and medication adherence in patients transitioned from insulin 70/30 vials to 70/30 pens. According to a Resource and Patient Management System (RPMS) Query Manager (QMAN) utility search, 768 patients received both insulin 70/30 vials and 70/30 pens between June 1, 2015 and December 31, 2017. This date range was chosen to include time of formulary addition and ensure largest number of patients available for review. Patients included were those transitioned from 70/30 vials to 70/30 pens, having at least six months of therapy on each dosage form, and documented at least two A1C measurements on each dosage form. Patients restarted on 70/30 vials, transitioned to alternate insulins, or started on additional insulins were excluded from the study. Primary outcome data will be A1C comparison between vials and pens. Utilizing a two-sided paired t-test to determine statistical difference, a pilot study determined 263 charts should be reviewed to provide adequate power for A1C evaluation. The pilot estimates 54% of patients will be excluded. Therefore, to ensure validity 550 charts will be randomly selected for reviewed. Adherence will be assessed using the Portion of Days Covered formula, then evaluated using the two-sided paired t-test.
Results: not applicable
Conclusion: not applicable
Billie Evans– PGY1 Pharmacy Resident, Northern Navajo Medical Center, Farmington, NM