Category: Federal Forum Posters
Purpose: Appropriate dosing, administration, and monitoring is critical to optimizing safe and effective use of vancomycin, an antibiotic used to treat infections caused by methicillin-resistant staphylococci. Subtherapeutic levels pose risk of treatment failure and development of vancomycin-resistant bacteria. Conversely, supratherapeutic levels pose risk of toxicities such as nephrotoxicity. A drug utilization evaluation conducted on intravenous vancomycin at the Washington DC Veterans Affairs Medical Center found inaccurate dosing, administration, and monitoring. The purpose of this study is to evaluate the impact of implementing a vancomycin dosing program at the Washington DC Veterans Affairs Medical Center.
Methods: This study is under review by the Institutional Review Board. An initial retrospective chart review will be conducted for baseline information on intravenous vancomycin use on all inpatient adults. Information on vancomycin dosing, medication administration logs, culture and sensitivities, and lab values including vancomycin troughs and serum creatinine will be collected. All data will be recorded without patient identifiers and maintained confidentially. Utilizing this chart review and primary literature, a vancomycin dosing nomogram will be created by the research team, Antimicrobial Stewardship (AMS), and Infectious Disease (ID). The research team and chief of the hospitalists will hold training sessions for providers and pharmacists. Following hospital-wide implementation of the vancomycin dosing nomogram, a retrospective chart review will be conducted for information on intravenous vancomycin use on all inpatient adults. The research team will then compare number of therapeutic trough levels and vancomycin-associated nephrotoxicity before and after implementation of the vancomycin dosing program at the Washington DC Veterans Affairs Medical Center.
Results: Not applicable
Conclusion: Not applicable
Tiffany Lee– Pharmacy Resident, Washington DC Veterans Affairs Medical Center, Fairfax, VA