Category: Federal Forum Posters
Purpose: Bacteremia is associated with lengthy hospital stays, long courses of antibiotics, and high rates of mortality. Assuring that patients receive the correct antibiotic for the pathogen causing their infection is vital to achieving resolution of infection. Simultaneously, limiting patient exposure to unnecessary antibiotics prevents antibiotic-related side effects and potentially prevents development of antimicrobial resistance. Implementation of rapid diagnostic testing in microbiology labs helps shorten the time it takes to identify the offending pathogen in blood cultures. This study will evaluate two specific technologies implemented at this institution for blood culture pathogen identification, Cepheid GeneXpert and Biofire FilmArray BCID panel.
Methods: Patients with positive blood cultures, after the time of implementing new rapid diagnostic technologies from November 2017-August 2018, will be evaluated. This group will be compared with patients that had positive blood cultures before rapid diagnostic techniques were implemented, from November 2015-August 2016. Data will be gathered using reports from rapid diagnostic technology platforms, Theradoc, and CPRS. Additionally, this institution is not operating the rapid diagnostic technology during all shifts due to staffing. Outcomes will also be evaluated based on the time of day that cultures were evaluated and communicated to providers.
The primary outcome will be time to appropriate antimicrobial therapy. Secondary outcomes will be duration of antimicrobial therapy from time of positive culture, duration of antimicrobial therapy for patients with Staphylococcus sp. Infections, length of hospital stay, length of ICU stay, 30-day mortality, and 90- day recurrence. Bivariable statistics including student’s t-test, Wilcoxon Rank Sum, chi-square test, or Fisher’s exact test will be utilized as appropriate.
Anndee Gritte– Student, University of Texas at Austin College of Pharmacy, San Antonio, TX