Category: Federal Forum Posters
Purpose: The objective of this study is to determine the risk of nonselective alpha-1 blockers and development of adverse drug events (ADEs) in a veteran population. Nonselective alpha-1 blockers are commonly used for the treatment of benign prostatic hyperplasia, post-traumatic stress disorder, and nightmares. Adverse effects include dizziness and orthostatic hypotension, which can increase the risk for fall-related injuries resulting in emergency department visits and hospital admissions, especially in patients who are elderly or have other risk factors. This study will enhance knowledge of how alpha-1 blockers are being used and will help to determine criteria for appropriate use.
Methods: A retrospective analysis of computerized medical records from a cohort of veterans at the Memphis VA Medical Center will be conducted. An SQL query will be performed to identify patients newly initiated on nonselective alpha-1 blockers. Patients will be categorized into one of two groups (“at risk” versus “control”) determined by prescription appropriateness defined by clinical characteristics. The “at risk” group will comprise patients at a higher risk of ADEs, including those aged 65 and older (per Beers Criteria) or those receiving high initial doses of alpha blockade. The “control” group will include patients receiving prescriptions for nonselective alpha-1 blockers without noted additional risk. Baseline patient characteristics including age, indication, and initial dosing will be assessed. Both groups will be examined for 12-month outcomes. Outcomes will include emergency department (ED) visits or hospital admissions, including those potentially due to ADEs following the initiation of an alpha-1 blocker. Relative risk between nonselective alpha-1 blockers and development of ADEs including those requiring hospitalizations or ED visits will be calculated. Safe prescribing habits for alpha-1 blockers within a veteran population will be determined and education provided as necessary.
Results: Not applicable
Conclusion: Not applicable
Chelsea McDonnell– PGY1 Pharmacy Resident, Memphis VA Medical Center, Memphis, TN