Category: Federal Forum Posters
Purpose: Trials that have assessed whether amiodarone prophylaxis decreased the incidence of atrial fibrillation in cardiac surgery patients have had mixed results. Prior to September 2017, VAPSCHCS cardiac surgery patients received prophylactic amiodarone. Currently, cardiac surgery patients do not receive amiodarone prophylaxis. The objective of this retrospective study is to determine the incidence of atrial fibrillation in cardiac surgery patients with and without amiodarone prophylaxis at VAPSHCS.
Methods: A retrospective chart review will be performed on 50 VAPSHCS cardiac surgery patients before and after September 2017. The two study populations will include 1.) cardiac surgery patients prior to September 2017 who received amiodarone prophylaxis and 2.) cardiac surgery patients after September 2017 who did not receive amiodarone prophylaxis. Patients over 18 years of age who have had cardiac surgery will be included in this study. Exclusion criteria will include patients with a history of chronic atrial fibrillation, patients who returned to the operating room within 5 days or developed stroke or heart block post-operatively, or patients who did not qualify to receive amiodarone due to an amiodarone allergy/sensitivity, bradycardia, baseline QTc >480ms, or elevated liver function tests (LFTs) >2 times normal or an established diagnosis of cirrhosis. Pre-operative data will include: short-term risk score (STS); intra-operative data will include: cross clamp time, bypass time, and fluid balance; post-operative data will include: time to extubation, vasopressor use, beta-blocker use, time to start beta-blocker post-surgery, IV or PO beta-blocker use, daily fluid balance during intensive care unit stay, and post-operative day (POD) when diuresis initiated.
Results: Not applicable
Conclusion: Not applicable
Emily Perinovic– Pharmacy Resident, VA Puget Sound Health Care System, Milwaukee, WI