Category: Federal Forum Posters
Purpose: Empiric selection of antibiotics for treating cystitis in men is complicated by limited data and high resistance rates to Escherichia coli. At our institution, there is no formal guidance on how to empirically treat outpatient cystitis in males. Thus, our study aims to compare cystitis recurrence rates among male outpatient veterans receiving cefpodoxime with ciprofloxacin to determine appropriate empiric therapy. We hypothesize that there is no difference in response rates among male outpatient veterans receiving these two antibiotics.
Methods: This study is a retrospective analysis of cefpodoxime and ciprofloxacin used to treat E. coli cystitis in male veterans. The primary outcome will be recurrence of cystitis, defined as early (less than or equal 30 days since index date) or late (greater than 30 days). The secondary outcome will include an analysis of changes in therapy based on susceptibilities. Comparisons between cefpodoxime and ciprofloxacin regarding duration of therapy, subsequent hospital admissions, and Clostridium difficile infections will be conducted. Male veterans with a diagnosis of cystitis with a positive E. coli urine culture and at least one outpatient antibiotic for cystitis between January 1, 2016 to December 31, 2017 will be included. Exclusion criteria will include those diagnosed with prostatitis, severe cases (defined as those receiving more than 3 antibiotics), and patients whose index cases were within 30 days of a prior episode. Patients will be selected using electronic data capturing obtained through standard query logic and VA informatics and computing infrastructure (VINCI). Information regarding duration and dose of antibiotics, health outcomes, and patient characteristics will be collected. Multivariate analyses of cystitis risk factors, recurrence, and treatment antibiotic will be conducted. This study and its protocol are pending submission to IRB.
Results: not applicable
Conclusion: not applicable
Jessica Yang– PGY1 Pharmacy Resident, South Texas Veterans Health Care System, San Antonio, TX