Category: Federal Forum Posters
Purpose: Treatment after solid organ transplant is complex and crucial to survival, requiring comprehensive patient education and medication monitoring. Nonadherence to immunosuppression maintenance therapy could be harmful and potentially fatal. Furthermore, therapy is costly, thus many veterans who've undergone solid organ transplantation seek prescriptions through the VA. Currently at this VA facility, primary care providers are requested to prescribe necessary anti-rejection therapy, although standardized monitoring are not established. The purpose of this medication use evaluation is to evaluate solid organ transplant immunosuppression maintenance therapy monitoring and to identify areas for potential quality improvement to foster positive patient outcomes.
Methods: A retrospective chart review of patients with an active outpatient prescription for an immunosuppressant for solid organ transplant between July 1, 2017 and July 31, 2018 will be performed. The following data will be collected: name, dose, and quantity of immunosuppressant prescribed, refill history, type of transplant, relevant laboratory parameters per immunosuppressant, concurrent prescription for CYP- 450 inducers or inhibitors, reported adverse events and hospitalizations. Patients will be stratified based on location of solid organ transplantation; either within the VA or outside the VA. Medication possession ratio (MPR) will be calculated to determine adherence to immunosuppressant. Patients will be classified as adherent if the amount of medication dispensed to the patients is at least 80% based on day supply of medication divided by the number of days the patient should be taking the medication. Frequency of laboratory monitoring will be assessed for accordance with current recommendations.
Results: Not applicable
Conclusion: Not applicable
Daniella Antolos– PGY1 Pharmacy Resident, VA Boston Healthcare System, Flushing, NY