Category: Federal Forum Posters
Purpose: Selection of an antipsychotic is a collaborative decision made by the patient and his or her care team based on patient characteristics and preferences. Olanzapine has a propensity to induce weight gain as well as cardiovascular and metabolic abnormalities. Previous data reported from this study determined a strong, positive correlation between Body Mass Index (BMI) at week eight and week twenty-four of olanzapine therapy, suggesting this period in therapy is a critical decision point regarding continuation of olanzapine. The purpose of this study is to further investigate associations between patient-specific characteristics and potential adverse metabolic effects of olanzapine.
Methods: This study has been approved by the Institutional Review Board. The electronic medical record will identify patients who have been newly prescribed olanzapine between 9/1/2006-8/31/16. Metabolic monitoring parameters including body weight, body mass index (BMI), hemoglobin A1c (HbA1c ), and lipids will be gathered at baseline and quarterly for one year following the initiation of olanzapine. Patient demographics and characteristics will be gathered, including psychiatric and relevant medical diagnoses, previous antipsychotic trials, and prescription of other medications associated with this study’s targeted metabolic changes. Primary outcomes include significant changes in metabolic outcomes. Secondary outcomes include medication adherence and time to olanzapine discontinuation rates. Metabolic outcomes data will be compared to patient-specific variables as well as medication acquisition data and statistical analysis will be performed to identify potential associations and to determine the significance of these associations. Linear regression will be performed to analyze the relationship with changes in the targeted metabolic outcomes. Logistic regression will be used to analyze the relationship with patient characteristics.
James Handshaw– PGY1 Pharmacy Practice Resident, VA Maine Healthcare System, Augusta, ME