Category: Federal Forum Posters
Purpose: Antipsychotic medications have been associated with an increased QTc interval, which may potentiate the risk of Torsades de pointes (TdP), a life-threatening emergency.1-2 The risk of TdP may be further increased by concurrent use of other QTc prolonging agents, such as antiarrhythmics. Unfortunately, there is limited guidance regarding the monitoring and management of this drug interaction.3-4 This quality improvement project is designed to assess the current monitoring practices of concomitantly prescribed antipsychotic and antiarrhythmic medications at the VA Northeast Ohio Healthcare System.
Methods: This quality improvement project will utilize data collected through chart review of patients prescribed both an antipsychotic and antiarrhythmic agent concurrently in the past five years. The data will be used to evaluate potential defects in the current monitoring process. Once potential defects are identified, various process improvement strategies will be implemented. The primary objective is to increase the number of patients receiving proper electrocardiogram (ECG) monitoring to include all patients prescribed both an antipsychotic and antiarrhythmic agent concurrently and implement a standardized process to guide cardiologists, psychiatrists, and pharmacists through the management of this drug-drug interaction. Prospective data will be collected to assess effectiveness of each implemented strategy.
Results: not applicable
Conclusion: not applicable
Alison Dailey– PGY1 Pharmacy Practice Resident, Louis Stokes Cleveland VA Medical Center, Parma, OH