Category: Federal Forum Posters
Purpose: Post-procedural pain is commonly managed by opioid medications when acetaminophen and nonsteroidal anti-inflammatory drugs are insufficient for pain control. Respiratory depression associated with opioid use can prolong time to achieving physical therapy goals due to oversedation and lead to dependence, addiction, and overdose incidents. Peripheral nerve blocks are a diverse set of non-opioid analgesic agents that can serve as alternatives to reduce opioid consumption. This study aims to determine whether patients who use disposable ropivacaine 0.2 percent infusion pumps with concomitant opioids have decreased overall opioid requirements for post-procedural anesthesia and pain management after primary total knee replacements.
Methods: This retrospective, observational cohort analysis will include adult veterans who required post-procedural anesthesia or pain control from March 2017 to December 2018. Patients will be excluded based on the following criteria: patients with known allergy to any opioid medication or any amide-type local anesthetic and those who underwent total knee replacement for a second time. The following data will be collected: total daily dose of opioid(s) required at 24 hours, 72 hours, and 7 days after surgery in addition to the amount of opioid(s) prescribed upon discharge. Other data collected will include demographics, type of procedure, vital signs, laboratory data, concomitant medications, opioid usage prior to procedure, and prescriber information. Overall opioid requirement reduction will be analyzed using descriptive statistics, specifically the difference in mean milligram morphine equivalents between two groups: ropivacaine with opioids and opioids alone. Information regarding the study’s primary outcomes will be collected using the Computerized Patient Record System. Secondary objectives will be recorded and available. All patient data will be de-identified and maintained confidentially.
Results: not applicable
Conclusion: not applicable
Anna Chen– PGY1 Pharmacy Resident, VA Boston Healthcare System, Boston, MA