Category: Federal Forum Posters
Purpose: To determine if concomitant use of benzodiazepine receptor agonists or “Z drugs” impacts the successes or failures of evidence based post-traumatic stress disorder (PTSD) treatments including both psychotherapy and medications.
Methods: This Institutional Review Board-approved retrospective chart review will be used to assess a random sample of Veterans diagnosed with PTSD enrolled in the Battle Creek Veteran Affairs Medical Center Mental Health Clinic from October 1, 2013 to April 1, 2018 with two available PCL-5 scores completed 30 days apart at minimum. Participants will be excluded if they are on a benzodiazepine or barbiturate. Those meeting inclusion criteria will be reviewed to determine “Z” drug use as well as demographic information, diagnoses, therapy duration, type of evidence based therapy practiced, psychotropic medication prescription, including both antidepressants and antipsychotics, incidence of co-occurring substance use disorder, and PCL-5 scores. Treatment success will be defined as at least a 5-point reduction in score from baseline.
An explanatory model will be developed using logistic regression to examine the effect of “Z” drugs on success or failure of treatment in the outpatient mental health clinic, adjusting for other variables. Variables to be included in the initial model include “Z” drug use, time in treatment, antidepressant treatment, antipsychotic treatment, and other substance use disorders.
Results: Not applicable.
Conclusion: Not applicable.
Sara Shikwana– PGY1 Pharmacy Resident â€“ Mental Health, Battle Creek VAMC, Battle Creek, MI