Category: Federal Forum Posters
Purpose: Opioid use disorder can cause significant morbidity and mortality. Treatment with combination buprenorphine and naloxone can be effective, however there is conflicting evidence on the utility of higher doses in preventing relapses. Few studies analyze characteristics of Veteran patients, specifically the rate of relapse. In the Veteran population, no studies have examined the effect of dosing on the rate of relapse. This project was designed to assess combination buprenorphine and naloxone maintenance doses and the rate of relapse in the Veteran population with opioid use disorder at a Veterans Affairs Medical Center.
Methods: Medication fill records from January 1, 2014 to December 31, 2017 will be used to generate a list of patients treated with combination buprenorphine and naloxone in the Substance Use Disorders Rehabilitation Program (SUDRP) at the Richard L. Roudebush Veterans Affairs Medical Center. Patients will be categorized into two treatment groups; those taking less than 16 mg of buprenorphine and naloxone daily and those taking 16 mg of buprenorphine and naloxone or more daily. Patients will be excluded from the study if they are taking opioids other than buprenorphine and naloxone, those receiving care outside of the treatment program, if they are less than 18 years of age, or if they are pregnant. Treatment will be followed from determination of maintenance dose for 12 months or until relapse, whichever comes first. Relapse rates will be determined by self-report, or positive urine toxicology reports. The primary outcome investigated is rate of relapse between the two groups. Secondary outcomes include rates of relapse between daily dosing and take home patients, dosage formulation, time to relapse, provider prescribing differences and the use of other substances during treatment. All data will be obtained using the patient electronic medical record and data will be de-identified.
Results: Not applicable
Conclusion: Not applicable
Katie Binger– PGY1 Pharmacy Resident, Richard L. Roudebush VAMC, Indianapolis, IN