Category: Federal Forum Posters
Purpose: Statins are first-line in lipid management due to their ability to lower risk of cardiovascular events. Unfortunately, many patients are unable to tolerate statins due to adverse drug reactions (ADRs) such as myalgia. Previous studies have demonstrated a positive relationship between low vitamin D levels and statin-related muscle-ADRs and that correcting vitamin D deficiency improved rates of statin continuation. The purpose of this study is to assess if vitamin D supplementation improves continuation rates when rechallenging a statin in patients with documented muscle-related ADR and vitamin D deficiency.
Methods: This study is a retrospective chart review of veterans within a VA health care system who have experienced a muscle-related statin ADR while vitamin D deficient between January 1st, 2008 and October 1st, 2017. Patients will be identified using the Computerized Patient Record System and review of approved Lipid Consults. To be included for analysis, patients must meet the following criteria: 1) muscle-related statin ADR, 2) vitamin D level < 30 ng/mL within 180 days before or after statin ADR, and 3) were rechallenged with a statin within 180 days after qualifying statin ADR. Those who meet criteria will be divided into two groups – those who received vitamin D supplementation prior to statin rechallenge and those who did not receive vitamin D supplementation. These groups will be matched 1:1 based on gender and age. The primary endpoint of the study is the percentage of patients continuing to receive any statin at 6 months after initiation. Secondary endpoints include the percentage of patients continuing to receive any statin at 12 months, differentiation of vitamin D deficiency, the incidence of muscle-related stain ADRs during statin rechallenge, and treatment utilization for statins and vitamin D supplementation.
Results: not applicable
Conclusion: not applicable
Alison Compton– PGY1 Pharmacy Resident, Durham Veterans Affair Health Care System, Durham, NC