Category: Federal Forum Posters
Purpose: Truvada®, an FDA approved pre-exposure prophylaxis (PrEP) therapy, is an effective pharmacological method to help reduce the risk of HIV transmission. The use of Truvada® for PrEP requires monitoring including serum creatinine, Human Immunodeficiency Virus (HIV)/ Sexually Transmitted Infections (STI) testing, and pregnancy testing for females. Monitoring is important to ensure safety and avoid the development of HIV resistant strains due to inadequate therapy in HIV positive patients.
The objective of this project is to assess whether implementation of provider education will help improve PrEP’s follow-up monitoring and prescribing habits based on guideline indications and risk factors.
Methods: This quality improvement project will be submitted to Veterans Affairs (VA) Office of Research Administration for review and approval. Patients will be identified by utilizing the Veterans Information Systems and Technology Architecture (VISTA) program to detect and review patients who were initiated on Truvada® for PrEP. Data will be collected via routine patient chart review through the VA’s Computerized Patient Record System (CPRS). Data collected will include: demographic data and risk factors for initiating PrEP (if available). Results of renal function, hepatic function, and testing of HIV, STI, and pregnancy will also be collected. Providers will be educated on appropriate PrEP initiation and monitoring as well as given materials to use as a quick reference as this project’s intervention.
Pre- intervention and post intervention data will be collected and analyzed on the appropriateness of monitoring parameters as well as the prevalence of PrEP usage at this facility.
The primary outcome to assess is the appropriateness of HIV screening every 3 months. Secondary outcomes will include: appropriate PrEP initiation based on indication and risk factors, serum creatinine labs every 6 months, STI testing every 3-6 months, as well as pregnancy testing every 3 months for child bearing females.
Results: Not applicable
Conclusion: Not applicable
Jessica George Helou– Resident Pharmacist, Veterans Affairs Southern Nevada Healthcare System, Upland, CA