Category: Federal Forum Posters
Purpose: The purpose of this study is to assess the impact of long-term oral glucocorticoid therapy on glycemic control and hyperglycemia-related utilization rates of emergency healthcare services within the first year of glucocorticoid therapy. The results of this study may help to identify if there is a gap in current practice so that changes can be implemented to improve patient care.
Methods: The institutional review board approved this retrospective matched, cohort study. The electronic medical record system will be used to identify patients with an active outpatient prescription at the WJB Dorn VAMC for long-term glucocorticoid use as determined by a 30 day supply that was refilled in the subsequent month or greater than a 60 day supply. Patients will be enrolled from October 1, 2012 to October 1, 2016. Charts will be retrospectively reviewed for up to 18 months after the index date, which is the date of the first fill of the glucocorticoid prescription. A control group will be enrolled based on matched characteristics of the glucocorticoid group. Specific data to be collected includes: demographics, gender, date of birth, and baseline co-morbidities, basic metabolic panel, aspartate aminotransferase, and alanine aminotransferase. Oral corticosteroid prescription information will be obtained. Antidiabetic oral medications and insulin prescription data will be collected at baseline and 1 year after the index date. Hemoglobin A1C will be collected at baseline and 15 months after the index date. The primary outcome will be annual rate of hyperglycemia-related hospitalizations and emergency room visits in patients who were initiated on long-term oral glucocorticoids as compared to those who were not.
Dominic Leader– PGY1 Pharmacy Resident, William Jennings Bryan Dorn Veterans Affair Medical Center, North Huntingdon, PA