Introduction - Use of nanoparticles as a possible cancer therapy has intriguing potential. Studies are currently in progress that explore their use in immunotherapy, targeted therapy delivery, and thermal ablation. In this pilot study we employ a nanoparticle consisting of silicone and gold. Due to the unique nature of the nanoparticle design they vibrate when exposed to the appropriate wavelength of light generating controlled and targeted heat. Our hypothesis is that heat generated with laser light induced nanoparticle vibration will cause cancer cell death, thereby provide definitive therapy in low grade mast cell tumors.
Methods - 18 dogs with low grade mast cell tumors, < 1.5 cm, were randomized into either treatment or control groups. All dogs received Benadryl , 2 mg/kg/12 hours, and Pepcid AC, 0.5mg/kg/24 hours. On day one dogs received a 2 hour IV infusion of nanoparticles. On day two, the treatment group dogs had light therapy applied to the tumor using a diode laser - 810 nm, 12W/cm2. Dogs were evaluated once a week for four weeks and then monthly. Data collected included signalment, tumor size pre-infusion and pre-laser therapy application, response to therapy, duration of response, and any toxicities.
Results - All laser treated dogs responded and were in clinical remission by one month from laser therapy. Three dogs had recurrence at 3 and 4 months after therapy. No serious or long term toxicities were noted in any of the dogs.
Conclusion - Nanoparticle laser ablation therapy was effective in treating low grade mast cell tumors with a low risk of toxicities.
Olympia Veterinary Specialists
Lisa Parshley received her PhD in biochemistry prior to entering veterinary school. After achieving a doctorate in veterinary medicine from Colorado State University she successfully completed a rotating small animal medicine internship at Cornell University. In 2008 after completing an oncology residency from Michigan State University she was awarded diplomat status from the American College of Veterinary Internal Medicine specializing in Oncology. Currently Lisa works and owns the Olympia Veterinary Speciality practice.
Thursday, June 14
4:15 PM – 4:30 PM
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