Small Animal Internal Medicine

Research Abstract

ID08 - Investigation of the Association Between Lyme Seroreactivity and Chronic Kidney Disease in Dogs

Thursday, June 14
5:45 PM - 6:00 PM
Location: WSCC 307/308

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Borrelia burgdorferi, the causative agent of Lyme disease, is a common tick-borne pathogen known to infect dogs in the United States.  While infection with B. burgdorferi has a recognized, albeit uncommon, association with the onset of acute kidney disease, termed acute Lyme nephritis, less is known about associations between infection by this pathogen and the onset of chronic kidney disease in dogs. A retrospective cohort study was performed to determine if dogs with detectable antibodies to the VlsE C6 peptide of B. burgdorferi could be associated with an increased risk of kidney disease. Lyme serology data were obtained from the IDEXX Reference Laboratory (IRL) and in-clinic databases from 2003 through 2017. Chemistry and urinalysis results were obtained from the IRL database from July 2015 through January 2017. Patients exposed to VBD were defined as having a B. burgdorferi positive test result recorded at any point in time, while non-exposure was defined as having a negative result for all test events. For this study, chronic kidney disease (CKD) was defined as concurrent increased SDMA (> 14 µg/dL) and creatinine (> 1.5 mg/dL) for a minimum of 25 days with inappropriate urine specific gravity (USG B. burgdorferi, as evident by positive antibody to B. burgdorferi, within the defined Lyme region was found to be 1.43 with 95% confidence intervals [(1.27, 1.61), P < 0.0001]. This study identified an association between dogs with positive Lyme test results and a 43% increased risk for CKD.

Jennifer Ogeer, DVM, MS, MBA, MA

MEDICAL AFFAIRS MANAGER
IDEXX LABORATORIES INC.

A graduate of the Ontario Veterinary College, Dr. Jennifer Ogeer completed an emergency medicine/critical care residency at Tufts University/Angell Memorial Animal Hospital in Boston and an MSc degree (critical care) at the Ontario Veterinary College, Guelph. Her interests include kidney disease, coagulation, pancreatitis, and real-time PCR.

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ID08 - Investigation of the Association Between Lyme Seroreactivity and Chronic Kidney Disease in Dogs

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