Neurology

Research Abstract

N03 - Pharmacokinetics of Approved and Compounded Extended Release Levetiracetam After Single Oral Dose Administration in Cats

Thursday, June 14
10:45 AM - 11:00 AM
Location: WSCC 606/607

The half-life of levetiracetam (LEV) in cats approximates 3 hours, prompting the need for an extended release LEV (ER-LEV) formulation. The purpose of this study was to describe and compare pharmacokinetics of ER-LEV in both plasma and CSF in cats after a single dose of approved and compounded ER-LEV.

Using a non-randomized cross-over design, nine clinically healthy cats received a single dose of 500 mg of approved ER-LEV PO. Thirteen blood and 1-2 CSF samples were collected over 24 hours. After a one-week washout period, the study was repeated with a single oral dose of 500 mg compounded ER-LEV. LEV was quantitated by immunoassay. Plasma and pooled CSF LEV concentrations versus time data were subjected to noncompartmental pharmacokinetic analysis and data were compared between formulations using a paired t-test.


Regardless of formulation, CSF LEV closely mimicked plasma concentrations. Significant differences (P < 0.05) between formulations were limited to plasma Cmax (ug/mL) (approved 126 +/- 33; compounded 169 +/- 51) and tmax (approved 5.1 +/- 1.6; compounded 3.1 +/- 1.5). With a half-life of 12.6 +/- 1.6 hours and 12.7 +/- 2.0 for approved and compounded, respectively, both formulations maintained concentrations above the human therapeutic reference interval for at least 12 hours.


This study demonstrates that both approved and compounded ER-LEV maintains human therapeutic LEV concentrations in healthy cats 12 hours after oral administration, supporting 12-hour dosing intervals. This study also demonstrates that plasma LEV monitoring can be used as an accurate representation of CSF LEV concentrations in cats.

Erik R. Johnson, DVM

Resident of Neurology & Neurosurgery
Auburn University College of Veterinary Medicine

Presentation(s):

Send Email for Erik Johnson


Assets

N03 - Pharmacokinetics of Approved and Compounded Extended Release Levetiracetam After Single Oral Dose Administration in Cats

Handout

Attendees who have favorited this

Please enter your access key

The asset you are trying to access is locked. Please enter your access key to unlock.

Send Email for Pharmacokinetics of Approved and Compounded Extended Release Levetiracetam After Single Oral Dose Administration in Cats