The neurokinin-1 (NK) receptor antagonist maropitant citrate (Cerenia™, Zoetis Services) is commonly used in cats and dogs to mitigate nausea and vomiting. While horses do not vomit, nausea is poorly understood and likely under recognized in this species. In dogs and cats maropitant has significant visceral analgesic properties, as well. Investigation into the use of NK-1 receptor antagonists in horses has not been reported. The purpose of this study was to determine the pharmacokinetic profile of maropitant citrate in seven adult horses after a single intravenous (IV; 1 mg/kg) and intragastric (IG; 2 mg/kg) dose. A randomized, crossover design was performed and blood samples were collected serially after maropitant administration. Plasma maropitant concentrations were measured using LC-MS. Pharmacokinetic parameters were determined using noncompartmental analysis. The mean (± SD) plasma maropitant concentration 3 min after IV administration was 0.80 ± 0.14 µg/mL, elimination half-life was 10.37 ± 2.07 h and volume of distribution was 6.54 ± 1.84 L/kg. The mean (± SD) maximum concentration following IG administration was 0.08 ± 0.04 µg/mL and elimination half-life was 9.64 ± 1.27 h. The oral bioavailability was variable (13.31 ± 5.30%). Maropitant concentrations achieved after IG administration were comparable to those in canines and felines, however concentrations after IV administration were lower and higher than dogs and cats, respectively. Elimination half-life was longer than that in dogs and shorter than in cats. This study describes the pharmacokinetic profile of single dose maropitant in horses and can serve as the basis for further pharmacologic investigations.
UC Davis Veterinary Medical Teaching Hospital
Obtained Diplomate of Veterinary Medicine status at the University of California, Davis, School of Veterinary Medicine in 2010
Completed the Large Animal Internal Medicine Residency at the University of California, Davis, School of Veterinary Medicine in 2016
Obtained Diplomate of the American College of Veterinary Internal Medicine status in 2016
Current Staff Veterinarian for Equine Field Service and Internal Medicine at the University of California, Davis, Veterinary Medical Teaching Hospital
Friday, June 15
4:15 PM – 4:30 PM
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