The intent of this research is to identify a simple diagnostic test to detect abnormal calciuresis and predict calcium oxalate (CaOx) urolith presence in Miniature Schnauzers. We are investigating the impact of postprandial time on the specificity of urine calcium:creatine (UCa:Cr) in identifying affected dogs.
The hypotheses are: 1) Significant differences exist in fasted and postprandial UCa:Cr between urolith-forming and control schnauzers. 2) UCa:Cr increases significantly from fasted baseline at one or more postprandial time point(s).
Urine samples are being collected from Miniature Schnauzers with (urolith-formers) and without (controls) CaOx uroliths in a fasted state and 1, 2, 4, and 8 hours after feeding a standardized diet. The change in UCa:Cr from baseline was calculated for each postprandial time. Urolithiasis status and the time point were assessed for impact on the UCa:Cr and change in UCa:Cr using a mixed model ANOVA.
Based on 7 urolith-forming and 12 control dogs enrolled thus far, urolith-forming Miniature Schnauzers have significantly higher mean UCa:Cr at 1 hour, 4 hours and 8 hours postprandial timepoints indicating altered calciuresis. The change in UCa:Cr was not significant at any post-prandial time point between or within groups.
Urolith forming Miniature Schnauzers have excessive calciuresis, providing insight into the mechanism behind their formation of CaOx uroliths. If using the Ca:Cr ratio, the postprandial sampling time is not critical. This simple urine measurement has potential as a marker of urolith presence and possibly risk of urolith formation.
3rd year Resident
Virginia Polytechnic and State University
Friday, June 15
1:30 PM – 1:45 PM
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