Small Animal Internal Medicine

Research Abstract

ID01 - Risk Factors for Candida Urinary Tract Infections in Dogs and Cats

Thursday, June 14
3:15 PM - 3:30 PM
Location: WSCC 307/308

Candida infections have been described in both dogs and cats. Limited data is available regarding risk of development of these infections. The objective in this study was to investigate risk factors associated with development of Candida urinary tract infections in dogs and cats.


 Eighteen dogs and eight cats with culture-confirmed candiduriawere evaluated in  a retrospective case-control study to identify risk factors associated with candiduria. Control dogs and cats had bacterial cystitis or cutaneous Malassezia infection (dogs only). Univariate exact logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals.  P-values < 0.05 were statistically significant.


 Administration of antibacterial drugs in the 30 days before diagnosis was associated with candiduria in dogs using controls with bacterial cystitis (OR 14.5; 95% CI 3.1-66.9) and with Malassezia infection (OR 26.4; 95% CI 3.4-206.7).  Antibacterial drug administration was also associated with candiduria in cats (OR 15.7; 95% CI 1.9-132.3).  Immunosuppression was associated with candiduria in dogs when compared to controls with Malassezia infection (OR 4.2, 95% CI 1.4-12.8) but not significantly with bacterial cystitis controls (OR 2.7, 95% CI 0.9-8.0). Lower urinary tract diseases other than infection were associated with candiduria in cats (OR 6.7, 95% CI 1.6-27.9), but not significantly in dogs (OR 2.5, 95% CI 0.7-8.7). Neither diabetes mellitus nor history of hospitalization was significantly associated with candiduria in either species.


 Recent administration of antibacterial drug therapy was a potential risk factor for development of candiduria in this population; their judicious use may help prevent this fungal infection. 


 


 

Krystle L. Reagan, DVM, PhD

Small animal internal medicine resident III
University of California, Davis

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