Neurology

Research Abstract

N06 - Serum Levetiracetam Concentrations Following Chronic Administration of Three Times Daily Transdermal Levetiracetam in Six Cats

Thursday, June 14
11:30 AM - 11:45 AM
Location: WSCC 606/607

The purpose of this prospective clinical trial was to 1) determine whether transdermal levetiracetam in Lipoderm vehicle (LL) results in serum concentrations ≥ 5 mcg/ml (minimum human therapeutic interval) following 6 days of every 8 hour administration in healthy cats and 2) identify any adverse drug reactions during the administration period. Six staff or student owned healthy cats weighing ≤ 5 kg were enrolled. Cats were determined to be healthy based on physical examination, neurologic examination, packed cell volume and total protein evaluation, and serum biochemistry panel. LL was applied to the inner pinna at a dosage of 60 mg/kg (400 mg/ml) at home for 6 days. On day 7, cats were hospitalized for serum levetiracetam sampling through peripheral venipuncture at times 0 (prior to dose administration), 30, 60, 120, 180, 240 and 300 minutes post administration.  Median (range) timed serum concentrations were 16.6 (8.6 - 39.6), 16.1 (6.8 - 34.4), 15.4 (10.1 - 36.7), 17.4 (9.2 - 32.7), 15.1 (8.3 - 25.9), and 14.8 (11.9 - 28.4) mcg/ml, respectively.  Adverse events were limited to sedation (cat 3: day 3). This study demonstrated that thrice daily transdermal LL resulted in median serum concentrations ≥ 5 mcg/ml throughout the sampling period and adverse events were minimal.  Additional studies are necessary to evaluate efficacy of transdermal LL in epileptic cats.

Casey J. Smith, BVM&S

Resident, Neurology/Neurosurgery
University of Madison-Wisconsin

Casey Smith is a current Neurology/Neurosurgery resident at the University of Wisconsin-Madison. She graduated from the University of Glasgow School of Veterinary Medicine in 2013. Following graduation, she completed a small animal rotating internship at the Pittsburgh Veterinary Specialty and Emergency Centre. She then completed a combined surgery and neurology internship at Mission Veterinary Specialists in San Antonio before moving home to Canada to complete a neurology internship at Canada West Veterinary Specialists in Vancouver, BC. Prior to accepting her residency position, she stayed on at Canada West Veterinary Specialists in an ER position. Her clinical interests include neurosurgery, neurologic emergencies, and imaging.

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