Small Animal Internal Medicine

Research Abstract

HP04 - Serum Vitamin D Status in Cats with Cholestatic Hepatobiliary Disease

Friday, June 15
5:30 PM - 5:45 PM
Location: WSCC 616/617

The liver performs an essential role in metabolism of vitamin D (VD); deficiency of vitamin K, another fat-soluble vitamin, is common in cats with cholestatic hepatobiliary disease (CHD). We hypothesized that VD levels in cats with CHD would be significantly lower than in normal cats or sick cats with non-hepatobiliary disorders. A prospective case control study was done comparing cats with CHD disease (defined by hyperbilirubinemia and increased alanine aminotransferase), sick cats without hepatobiliary disease, and normal cats represented by the validated reference range for 25(OH)VD. Thirty-six cats with CHD and 23 cats with non-hepatobiliary disease were enrolled. Parathyroid hormone (PTH), ionized calcium (iCa) and 25(OH)D were measured in all cats. Mean 25 (OH)VD levels were significantly lower in sick cats (89 nmol/L +/-24 nmol/L) and cats with cholestatic disease (88 nmol/L +/- 33 nmol/L) compared to the reference range (117 nmol/L +/- 26.2 nmol/L).  Median iCa and PTH in cats with CHD was significantly higher (1.32 mmol/L and 0.95 pmol/L respectively) than in sick cats (1.26 mmol/L and 0.65 pmol/L, respectively). Six of 36 (17%) of CHD cats and 1/24 (4%) of sick cats had high PTH levels. Overall 13/36 (36%) CHD cats and 7/24 (29 %) sick cats were 25(OH)VD deficient or insufficient (< 74 nmol/L). There was no correlation between 25(OH)VD and serum bilirubin. As inadequate 25(OH)VD may negatively impact overall health and low levels were common in all the sick cats in this study. Future studies assessing the impact of insufficient VD levels in cats are necessary. 

Cynthia Webster, BS DVM DACVIM (SAIM)

Professor and Associate Chair of Research
Tufts University, Cummings SVM

Cynthia Webster, BS, DVM, DACVIM (SAIM), is professor and associate chair of research in the clinical science department at the Cummings School of Veterinary Medicine at Tufts University.  Her clinical interests are in cholestatic liver diseases in dogs and cats. For the last 20 years her research interests have been focused on the role of bile acids as hepatotoxins that fuel the progression of cholestatic hepatic disease. She is program chair of the ACVIM Liver Study Group sessions and is currently serving as Chair of the ACVIM Consensus Group on chronic hepatitis in the dog. As a 30 year member of the American Association for the Study of Liver disease she has used her contacts in human hepatology to arrange a program with a one health theme. The topic of immune hepatitis and copper associated liver disease will be discussed by human and veterinary experts in the field and the diseases in each species contrasted and compared to hopefully yield increased understanding of these important categories of hepatic disease.

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HP04 - Serum Vitamin D Status in Cats with Cholestatic Hepatobiliary Disease

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