Oncology

Research Abstract

O05 - The Association Between Symmetric Dimethylarginine Concentrations and Neoplasia in Dogs and Cats

Thursday, June 14
2:30 PM - 2:45 PM
Location: WSCC 615

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The purpose of this study was to examine the association between SDMA concentrations in dogs and cats with different types of neoplasia. The IDEXX Laboratories pathology database was used to identify cases of lymphoma, hemangiosarcoma, mammary carcinoma, mammary adenocarcinoma, and lipoma in dogs, and lymphoma and visceral mast cell tumor in cats. Potential cases needed a serum SDMA and creatinine measured within 3-months prior to diagnosis. Control animals were randomly selected from the clinical laboratory database and age- and breed-matched (in dogs) and age-matched (in cats) to cases. SDMA and creatinine concentrations were compared between cases and controls by cancer type.  SDMA concentrations were significantly higher in dogs and cats with lymphoma (P < 0.0001) and significantly lower in dogs with lipoma, mammary adenocarcinoma and mammary carcinoma (P ≤ 0.003) as compared to controls. Creatinine concentrations were significantly lower in dogs with mammary adenocarcinoma and mammary carcinoma and in cats with lymphoma (p≤0.0008) when compared to controls. Odds ratios (OR) and 95% confidence intervals (CI) were calculated to determine the association between SDMA and tumor type (Table 1).

The results indicate that in both cats and dogs, cases of lymphoma are associated with increased SDMA concentrations with a large portion of these cases having concurrent creatinine concentrations within the reference interval. Although the etiology of increased SDMA concentrations in these cases was not determined, SDMA may be an early marker of renal involvement and reduced GFR in recently diagnosed cases of lymphoma.

Michael J. Coyne, VMD PhD

Clinical Studies Design Specialist
IDEXX Laboratories, Inc.

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O05 - The Association Between Symmetric Dimethylarginine Concentrations and Neoplasia in Dogs and Cats

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