Oral glucose tests (OGT) are currently recommended for diagnosis of insulin dysregulation (ID). As horses suffering from ID are prone to laminitis especially when exposed to high amounts of sugar it would be desirable to reduce the amount of diagnostic glucose. Furthermore, a reduced glucose amount enables various routes of application.
Aim of this study was to determine whether a dosage of 0.25g or 0.5g glucose per kg bodyweight (BW) instead of 1g/kg BW would be useful for clinical settings and sufficient to distinguish between insulin sensitive and insulin dysregulated horses.
Eighteen Icelandic horses of different sex, age, bodyweight and uncertain metabolic status were tested each by application of 0.25g/kg BW (LOGT), 0.5g/kg BW (MOGT) and 1g/kg BW (OGT) glucose dissolved in 2L water and administered via naso-gastric-tube. Blood samples were collected for five hours and were analyzed for insulin and glucose.
Blood glucose concentration was significantly lower in LOGT compared to OGT (P < 0.0004) from 60 minutes and significantly lower in MOGT compared to OGT from 90 minutes (P < 0.0001) after application. Insulin concentration after 30 minutes was significantly lower in LOGT compared to MOGT (P < 0.05) and OGT (P < 0.01). No statistically different insulin concentrations were detected between MOGT and OGT until 135 minutes (P < 0.001). Moreover, insulin dynamics in MOGT and OGT allowed satisfying differentiation in insulin sensitive and insulin dysregulated horses.
Summing up, a reduction of glucose to 0.5g/kg BW in OGT can be recommended without loss of diagnostic value.
Resident ECEIM, Research assistant
Clinic for Horses, University of Veterinary Medicine Hannover, Foundation
04/2018 – Present: Clinic for Horses, University of Veterinary Medicine Hannover, Foundation, Hannover, Germany
Doctoral Thesis - Comparison of various methods for quantification of equine insulin under clinical settings for assessment of insulin dysregulation in oral glucose test in horses and ponies
04/2017 – Present: Clinic for Horses, University of Veterinary Medicine Hannover, Foundation, Hannover, Germany
Residency European College of Equine Internal Medicine (ECEIM)
04/2016 – 03/2017: Clinic for Horses, University of Veterinary Medicine Hannover, Foundation, Hannover, Germany
10/2014 – 04/2018: Hannover Graduate School for Veterinary Pathobiology, Neuroinfectiology, and Translational Medicine (HGNI) - University of Veterinary Medicine Hannover, Foundation, Hannover, Germany
Clinic for Horses and Department of Physiology, University of Veterinary Medicine Hannover, Foundation, Germany
PhD in Veterinary Research and Animal Biology – Equine Metabolic Syndrome – (Patho-) physiological variations in insulin sensitivity, glucose homeostasis and lipid metabolism in lean and obese horses
Thursday, June 14
3:00 PM – 3:15 PM
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