Assessment of glomerular filtration rate (GFR) is important in veterinary and human medicine. Hyperthyroid cats have an increased GFR, which will decrease after successful radioiodine treatment and can hence be used as a model to investigate new and minimally invasive techniques to assess renal function.
The objective of this prospective study was to investigate the usefulness of a minimally invasive transcutaneous GFR (tGFR) monitor (NIC-Kidney) to assess renal function in cats with naturally occurring hyperthyroidism pre (t0) and 2 weeks post radioiodine treatment (t2).
Eight hyperthyroid cats were included of which 5 were euthyroid at t2. Three cats remained hyperthyroid, but had significantly reduced serum T4 concentrations. Plasma GFR (pGFR) and plasma half-life (pHL) were assessed by plasma sinistrin clearance. Transcutaneous half-life (tHL) was measured in parallel using a fluorescent marker (FITC-sinistrin) and the NIC-kidney device. Plasma data was used to calculate a species-specific conversion factor to determine tGFR from tHL. Overall pGFR and tGFR were significantly correlated (Spearman’s correlation r = 0.73, P = 0.0019). In 7/8 cats pGFR decreased by 26% (mean); 13-59% (range). It remained unchanged in 1 cat. Using tGFR, a decrease of GFR was identified in 6/8 cats with a decrease (25%; 5-40%). The remaining 2 cats showed a mild increase (9% and 32%, respectively).
Although results are not directly comparable, transcutaneous GFR assessments is a promising minimally invasive technique to allow for GFR estimation in small animals. Further research in a larger cohort is necessary to evaluate the full potential of this method.
Asst. Prof. Small Animal Internal Medicine
Department of Veterinary Clinical Sciences, Purdue University
Dr. Steinbach graduated from University of Bern, Switzerland. She completed a Residency in Small Animal Internal Medicine at the Justus-Liebig University, Giessen, Germany and The Royal Veterinary College, London, United Kingdom. After becoming board certified, Dr. Steinbach worked as a Clinical Instructor and Lecturer at the Justus- Liebig University in Giessen, Germany before joining Purdue University in 2015 as Assistant Professor of Small Animal Internal Medicine. She is a Diplomate of the American and European College of Small Animal Internal Medicine. Her main interests are nephrology and urology and she is the Director of the Purdue Veterinary Hemodialysis Service.
Friday, June 15
4:30 PM – 4:45 PM
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