Cephalosporins administration induces high shedding rates of extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae in humans. The objective was to prospectively evaluate the effect of different antimicrobial treatments on fecal shedding of ESBL-producing Enterobacteriaceae in horses.
Horses presented to the University of Zurich between 2014-2015 were randomly allocated to receive penicillin and gentamicin (P/G, n = 43) or cefquinome (CEF, n = 43) - if antibiotic treatment was needed - or no antimicrobial treatment (NOAMD, n = 33). Fecal samples were taken on admission (Day 0), 3 days after admission (Day 3) and 28 days after discharge (Day 28). Samples were semi-quantitatively cultured on ESBL-agar. Differences between groups were analysed using the Chi-square test, odds ratios and two-way repeated measures ANOVA.
Prevalence on Day 0 was not different between groups (p = 0.47). Horses treated with CEF and P/G were more likely to shed ESBL-producing Enterobacteriaceae compared to NOAMD on Day 3 (OR: 0.4, p = 0.07 and OR: 6.8, p = 0.04, respectively) and Day 28 (OR: 0.2, p = 0.02 and OR: 6.3, p = 0.003, respectively). ESBL counts increased from Day 0 to Day 3 in all groups (CEF p = 0.001, P/G p < 0.001, NOAMD p = 0.02). ESBL bacterial count was significantly higher in the P/G group compared to CEF and NOAMD group (p = 0.001 and p < 0.001, respectively) and was also significantly higher in the CEF group compared to NOAMD group (p = 0.001).
Hospitalization and antimicrobial treatment increases colonization with ESBL-producing Enterobacteriaceae. Administration of cefquinome did not induce higher shedding rates compared to administration of penicillin/gentamicin as a standard antibiosis. This highlights the need for reducing antimicrobial use overall.
Senior Clinical Lecturer
University of Zurich
Angelika Schoster graduated from the DVM program of the University of Veterinary Medicine Vienna, Austria in 2006. She then successfully completed a 2 year graduate degree at the same university in 2008 followed by a Large Animal Internal medicine Residency and 3- graduate doctoral degree (DVSc) at the Ontario Veterinary College, Guelph, Ontario, Canada. She obtained ACVIM board certification in 2011. She then completed a PhD at the University of Copenhagen, Denmark in 2015. Since 2012 she has been a Senior Clinical Lecturer at the Clinic for Equine Internal medicine at the University of Zurich Switzerland.
Thursday, June 14
10:10 AM – 11:00 AM
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