Small Animal Internal Medicine

Research Abstract

NU11 - Assessment of Symmetric Dimethylarginine and Creatinine Concentrations in Cats with Urethral Obstructions

Friday, June 15
2:15 PM - 2:30 PM
Location: WSCC 616/617

The purpose of the study was to evaluate symmetric dimethylarginine (SDMA) and creatinine concentrations in cats with urethral obstructions (UO), and to determine if pre-decompression values correlate with post-decompression values.


 


Sixty-one cats admitted for treatment of a UO were eligible for inclusion. Serum SDMA and creatinine concentrations were assessed at presentation, 24 hours post-decompression, and 5-20 days post-decompression. Urinalysis and culture were assessed at presentation and at final follow-up. Cats were excluded if they had: bacterial growth on culture, evidence of re-obstruction, or failure to obtain all samples.


 


Twenty percent of cats (n = 12) were excluded due to a urinary tract infection (UTI) at presentation. The mean SDMA and creatinine were significantly higher in these cats (59.6 μg/dL and 11.7 mg/dL, respectively), compared with those without a UTI (27.6 μg/dL and 4.76 mg/dL, respectively) (p < 0.002, < 0.001).


 


Twenty-six cats met the inclusion criteria. There was a significant positive correlation between SDMA and creatinine at the time of UO (ρ = 0.732, p < 0.0001). There was no association between initial SDMA and SDMA post-decompression at 24 hours (p = 0.817) or 5-20 days (p = 0.744). Mean SDMA and creatinine at presentation (24.7 μg/dL and 4.4 mg/dL, respectively) were significantly higher compared with final values (13.7 μg/dL and 1.7 mg/dL, respectively) (p < 0.017, < 0.016).


 


SDMA appears to be a useful marker of post-renal azotemia in cats with UO, and pre-decompression SDMA does not reflect underlying kidney disease. UTIs may be more frequent in cats with UO than historically suggested, and screening should be considered, especially if SDMA and creatinine concentrations are elevated. 

Kendall E. Wilson, DVM

Resident, Internal Medicine
The Animal Medical Center

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