Cardiology

Research Abstract

C14 - Acute Phase Proteins in Cats with Congestive Heart Failure Due to Primary Cardiomyopathy

Friday, June 15
2:00 PM - 2:15 PM
Location: WSCC 613/614

Inflammatory responses occur in congestive heart failure both in humans and in dogs. Previous feline cardiomyopathy research suggests that inflammation plays a role in the disease process. The objective of this study was to assess circulating acute phase proteins in feline patients with congestive heart failure (CHF) due to primary cardiomyopathy (CM).

The study population included 15 CHF cats, 9 asymptomatic CM cats and 16 healthy controls. A panel of serum acute phase proteins were measured using Spatial Proximity Analyte Reagent Capture Luminescence (SPARCL) kits. Clinical and echocardiographic data were collated for the CM cats. Survival status of the CHF cats was recorded. One-way analysis of variance (ANOVA), Student’s T tests, chi-square and Fisher exact tests, Spearman’s rho and Cox proportional hazards models were used for statistical analysis.

Cats with CHF had: higher serum leucine-rich alpha-2-glycoprotein1 compared to healthy controls; higher serum amyloid A compared to asymptomatic CM and healthy controls; higher ceruloplasmin compared to asymptomatic CM (P < 0.05). In univariate survival analysis models, serum alpha-1-acid glycoprotein (AGP) level was found to be associated with a higher risk of death in CHF cats (P = 0.007). Multivariable analysis suggested that serum AGP (P = 0.009), body weight (P = 0.023) and LA/Ao ratio (P = 0.013) were independent prognostic factors in CHF cats.

Findings suggest that systemic inflammatory response occurs in feline congestive heart failure due to primary cardiomyopathies. Acute phase proteins can be used with other clinical parameters or biomarkers for disease monitoring and prognostication in feline cardiomyopathies.

Mengmeng Liu, BAgr PhD MRCVS

Postgraduate Student
Small Animal Hospital, School of Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK

I graduated from China Agricultural University in 2008. During my undergraduate study, I developed a strong interest in small animal cardiology. In 2009 I started a PhD program at the University of Edinburgh, investigating canine mitral valve disease pathogenesis. The main research project of my PhD and post-doctoral was tissue engineering canine mitral valve as an in vitro research model for canine mitral valve disease. In 2016, I passed the MCRVS exams and decided to return to clinical field for advanced training in small animal cardiology. In 2017, I joined a cardiology internship combined with a research master program at the University of Glasgow. My current research interest is developing novel biomarkers for feline congestive heart failure due to primary cardiomyopathy.

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