Neurology

Research Abstract

N12 - Accuracy of a Novel Magnetic Resonance Imaging-Based Patient-Individual Stereotactic Brain Biopsy Device in the Dog

Thursday, June 14
2:00 PM - 2:15 PM
Location: WSCC 606/607

The aim of the study was to determine the precision of the novel MRI-based patient-individual stereotactic brain biopsy device in dogs.  


Twenty-two canine cadavers with 2 target points each were used to determine accuracy. First, specific bone anchors and MRI-markers were secured to canine cadaver heads. Afterwards CT and MRI examinations of the heads were performed. Two target points and corresponding trajectories were defined on each MRI: left caudate nucleus and right piriform lobe. Based on MR-images, patient-individual frames including rigid needle placement ports to reach defined target points were constructed and printed with a 3D-printer. The needle was to enter the brain in a gyrus and not to penetrate the ventricles. The frames were secured to the bone anchors. Minimal-invasive access to the brain was created using a tool guide. The biopsy needle was placed through the needle placement port up to the predetermined depth. Afterwards CT examinations of the heads with biopsy needles placed in each target point were performed. Needle placement error was determined after fusion of MRI and CT examinations. Error was defined as deviation in mm between needle tip and anticipated target points.


The total median needle placement error for all 42 target points was 0.84 mm (range: 0.09-2.76; outlier: 4.11). The median needle placement error for the caudate nucleus only was 0.67 mm (range: 0.09- 1.25) and for the piriform lobe 0.85 mm (range: 0.14-2.76). Therefore, the MRI-based patient-individual stereotactic brain biopsy device reaches higher accuracy than most other described brain biopsy systems.       

Thomas Flegel, DACVIM (neurology), DECVN

Head of the Servive for Neurology and Neurosurgery
Department of Small Animal Medicine, University of Leipzig

1986-1992 studying veterinary medicine Humboldt-University Berlin, Germany
1992-1996 Assistent Dept. of Internal Veterinary Medicine and Dept. of Veterinaty Surgery, Humboldt-University Berlin, Germany
1996-1998 Assistent in private Small Animal Hospital, Berlin, Germany
1998-1999 Clinical Instructor in Neurology, North Carolina State University
1999-2001 Residency in Neurology, The Ohio State University
since 2002 Head of the Service of Neurology/Neurosurgery, Dept. Small Animal Medicine, University of Leipzig, Germany

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