Poster Presentation

Poster Presentation

PR02 - Augmentation of Copper Iodide Nanoparticles in Mineral Trioxide Aggregate and Its Efficacy Against Enterococcus Faecalis

Thursday, April 26
10:00 AM - 1:00 PM
Room: Exhibit Hall

Introduction: Mineral trioxide aggregate (MTA) and other similarly composed bioceramic materials have become a mainstay in modern endodontics demonstrating excellent sealing capabilities, slight expansion rather than shrinkage, low cytotoxicity and good biocompatibility. Recently, metallic nanoparticles have been used for a number of medical applications. Nanoparticles of copper and silver, specifically, have demonstrated long-term antimicrobial activity against a variety of Gram-positive and Gram-negative microbes. Here we evaluated the antibacterial effect that copper iodide nanoparticles conferred to MTA. Methods: CuI nanoparticle augmented MTA (MTA-CuI) was formed into 5 mm disks containing final concentrations of 1, 1.5, 3, and 10 mg per disk resulting in an exposed surface area of 86.4 mm2.  Disks of MTA-CuI, MTA, and gutta-percha were placed into a tryptic-soy broth plus 2% dextrose sufficient to support the establishment of a biofilm of Enterococcus faecalis. Disks were removed after 24 hours of exposure, gently washed and subjected to live/dead staining in order to assess the antimicrobial properties of the augmented MTA. Results: The biofilm model employed was sufficiently sensitive to detect changes to growth of the biofilm-community.  The copper iodide augmented MTA was most effective at its highest concentration with the other concentrations behaving essentially identically. Conclusion: MTA-CuI can limit biofilm growth and effectively reduce the concentration viable cells of E. faecalis thereby prompting a discussion of whether augmented materials can offer improved outcomes for endodontic therapy.

Craig A. Atchison

Post-graduate Endodontic Resident
Medical University of South Carolina

I'm from St. Louis, MO and attended the University of Missouri - Kansas City School of Dentistry. After being in private practice for 6 years, I began my post doctoral endodontics training at the Medical University of South Carolina in 2016.

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Michael Schmidt

Professor and Vice Chair Department of Microbiology and Immunology
Medical University of South Carolina

Dr. Schmidt is a professor and vice-chairman of the Department of Microbiology and Immunology at the Medical University of South Carolina and the lead researcher investigating the role of antimicrobial copper in health care.

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Zachary Evans

Assistant Professor

Dr. Zachary Evans is a periodontist and faculty member at the Medical University of South Carolina College of Dental Medicine. He has a Ph.D in immunology and microbiology .

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Attaway Hubert

Research Technician

Hubert Attaway is a research technician in the Department of Microbiology and Immunology at the Medical University of South Carolina. He assisted in designing protocols for the lab portion of this research.

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Umadevi P. Nair

Associate professor

Dr. Umadevi Nair served as the post-graduate director of Endodontics at the Medical University of South Carolina. She is a Diplomat of the American Board of Endodontics.

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