Poster Presentation

Poster Presentation

PR23 - Relationship Between HbA1c and Short-Term Healing of Periapical Lesions after Root Canal Treatment: An Interim Analysis

Thursday, April 26
10:00 AM - 1:00 PM
Room: Exhibit Hall

The purpose of this study was to examine the relationship between HbA1c level and short-term healing of periapical lesions after root canal treatment. This clinical study recruited 47 participants from the Postgraduate Endodontics Clinic at the University of Maryland School of Dentistry beginning in 2015.  After treatment, digital periapical radiographs were taken using a custom jig and blood samples drawn for HbA1c analyses. To assess short-term healing, participants returned after six months for a radiograph and blood draw. Two calibrated endodontists scored periapical lesions using the periapical index [PAI]. Kappa-analysis and Mann-Whitney U-test were used to determine inter-endodontist agreement and the differences between the post-operative and follow-up images, respectively. The relationship between HbA1c level and short-term healing was revealed with Pearson’s correlation [all, p<0.05]. Forty-seven participants had a mean HBA1c of 5.84% [SD±0.65%]. Out of 47 participants, nine who attended the short-term healing recall showed a baseline mean HBA1c of 5.58% [SD±0.41%] and 5.57% [SD±0.39%] six months later [p>0.05]. Kappa-value [k=0.768] revealed inter-evaluator agreement.  A significant decrease was found between the immediate postoperative and recall PAI scores [4.11 and 2.89, p<0.05]. A negative correlation was found between HbA1c level and short-term healing of periapical lesions, although it was not significant [r=-.382, p>0.05]. Of the 47 enrolled participants, 43 were self-reported non-diabetics. Of the self-reported non-diabetics 51.2% had an HbA1c that classified them as pre-diabetic or diabetic. This interim analysis suggests a trend for short-term healing of periapical lesions to be affected by HbA1c levels.

Zuwu Zhou

Endodontic Resident
University of Maryland

Dr. Zuwu Zhou graduated from the University of Maryland at College Park with a Bachelor of Science in Neurobiology. He earned his DDS degree from New York University College of Dentistry. Dr. Zhou joined the Bellevue/NYU Program for Survivors of Torture to provide comprehensive dental care for patients who had experienced torture and war trauma from over 70 countries. After graduating from dental school, he completed a general practice residency program at Flushing Hospital where he received additional training in general dentistry, endodontics, periodontics, pedodontics, prosthodontics, and oral surgery. He joined a group practice and practiced general dentistry for two years on the Eastern Shore of Maryland before starting Endodontics residency program at University of Maryland School of Dentistry.

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Tontesh Tawady

Private Practice

Dr. Tontesh Tawady graduated from The University of Maryland Baltimore County with a Bachelor of Science in Biology. He received his dental degree from the University of Maryland, School of Dentistry in 2012 and completed a general practice residency at the Philadelphia Veterans Affairs Medical Center. In 2016, Dr. Tawady completed a three-year endodontic residency at the University of Maryland Post-Graduate Endodontic Program with a masters degree.

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Patricia A Tordik

Program Director, Advanced Specialty Education in Endodontics
University of Maryland

1986-1990 DMD, University of New Jersey, 1995-1997 Certificate, Endodontics, New York University, 2006-2008 Program Director, Naval Postgraduate Dental School, 2013-Present Professor and Program Director, Advanced Specialty Education in Endodontics, University of Maryland

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Frederico C. Martinho

Clinical Associate Professor

Dr. Martinho graduated from Universidade Estácio de Sá in 2004 and earned his DDS. He received his certificate in Endodontics from the Naval Posgraduate Program in Rio de Janeiro, Brazil in 2005. He received his MS and PhD in Endodontics from State University of Campinas - São Paulo, Brazil in 2007 and 2011, respectively. Currently he is a clinical associate professor at the University of Maryland Dental School.

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Ashraf F. Fouad

Professor and Chair of Endodontics
University of North Carolina

Dr. Fouad obtained his DDS, Certificate of Endodontics and MS at the University of Iowa. He served as Assistant then Associate Professor of Endodontology at the University of Connecticut Health Center from 1992 – 2004, and as Chair of the Department of Endodontics, Prosthodontics and Operative Dentistry at the University of Maryland, from 2005 – 2015. He has been Freedland Distinguished Professor and Chair of Endodontics at the University of North Carolina since 2016.
Dr. Fouad has published over 65 manuscripts, 20 textbook chapters, over 120 abstracts, and edited and co-authored the textbooks: Endodontic Microbiology (now in its second edition) and the fifth edition of Endodontics: Principles and Practice. He is a Diplomate and Past President of the American Board of Endodontics, and an Associate Editor of the Journal of Endodontics. He has lectured widely in the U.S. and internationally, and his research interests include: endodontic molecular microbiology, effectiveness of antibiotic therapy, dental pulp regeneration, endodontic treatment outcomes and the pathogenesis and healing of periapical lesions in the host with normal and compromised systemic health.

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