Poster Presentation

Poster Presentation

PR80 - MicroRNA Profile of External Apical and Cervical Root Resorption

Thursday, April 26
10:00 AM - 1:00 PM
Room: Exhibit Hall

External root resorption (ERR) whether apical or cervical is challenging in prevention and treatment. Etiologic factors and pathogenesis are still poorly understood or descried. Therefore, there is need for better understanding of its molecular processes. In a recent study, a noticeable increase in has-miR548 was reported in inflamed pulp tissue. This miR548 was related to MAPK8 pathway which is responsible for inflammation due to mechanical stimuli. Since, the resorption is considered inflammatory in nature, microRNAs (miRNAs possibly is the pivotal molecule to regulate ERR pathogenies. Many studies identified miRNAs as a key player in inflammation and immunity. The aim of the present study was to characterize miRNAs expression pattern from resorptive tissues through micro-array analysis comparing thousands of known human miRNA. Samples collected from human apical and cervical external root resorption lesions were compared to normal human gingival tissue. A bioinformatics analysis was utilized to identify potential protein, cytokines and molecular pathway targets. Characterizing miRNA profiles will advance our understanding of the molecular processes that initiate and regulate root resorption and eventually can provide novel therapeutic strategies to halt or treat the resorptive process.

Sami Chogle

Associate Professor, Director and Chair of the Advanced Specialty Education Program; Department of Endodontics
Boston University

Associate Professor and Chair, Department of Endodontics
Director of the Advanced Specialty Education Program in Endodontics
BDS, Karnatak University, Dharwad, Karnatak, India
DMD, CAGS, MSD, Case Western Reserve University School of Dental Medicine

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Jacob Y. Al-Hashemi

Endodontic Resident
Boston University

BDS from Iraq 2006
Master of Science in Biomaterials from State University of New York at Buffalo 2013.
Doctoral of Science in Dentistry in Molecular and Cell biology at Boston University 2017
Currently first year Endo resident at Boston University.
My research focus on micro-RNA in inflammation and Bone regeneration.

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