Poster Presentation

Poster Presentation

PR37 - Primum Non Nocere - The Effects of Sodium Hypochlorite on Dentin as Used in Endodontics

Thursday, April 26
10:00 AM - 1:00 PM
Room: Exhibit Hall

NaOCl is a well-established irrigant for root canal treatment because of its antimicrobial and organic tissue dissolution capability. Little is known about the deleterious effect of this strong oxidizing agent on the integrity of mineralized dentin. Iatrogenically-induced loss of dentin integrity may precipitate post-treatment root fracture. Five laboratory procedures were completed in order to analyze the effects that various concentrations and exposure times of NaOCl had on dentin. The procedures included: transmission electron microscopy, size exclusion chromatography, fourier transform-infrared spectroscopy and flexural strength. Transmission electron microscopy provided evidence for collagen destruction in the surface/sub-surface of dentin treated with high NaOCl concentrations and long contact times. Size exclusion chromatography showed that the small hypochlorite anion degraded the collagen, and produced a 25–35 mm thick, non-uniform ‘‘ghost mineral layer” with enlarged, coalesced dentinal tubules. Fourier transform-infrared spectroscopy identified increases in apatite/collagen ratio in NaOCl-treated dentin. The apatite-rich, collagen-sparse dentin matrix that remained after NaOCl treatment was more brittle, as shown by the reductions in flexural strength. Understanding the deleterious effects of NaOCl on mineralized dentin enables one to balance the risks and benefits in using high NaOCl concentrations for lengthy periods in root canal debridement. Delineating the mechanism responsible for such a phenomenon may enable a high molecular weight, polymeric antimicrobial irrigant, with tissue dissolution capabilities, to be designed.

Brandon R. Griffin

Endodontic Resident
Georgia Regents University College of Dental Medicine

Dr. Griffin is currently an endodontic resident at the Dental College of Georgia at Augusta University. He earned a M.B.A. degree from the University of Phoenix prior to dental school. He earned his D.D.S degree from Dalhousie School of Dentistry in Halifax Nova Scotia, Canada. He returned home to his home state of Utah were he completed a G.P.R. program at the University of Utah Hospital of Medicine. Upon completion of the G.P.R. he moved to Augusta Georgia where he completed an Internship in Oral Maxillofacial Surgery. One year of practice as a general dentist in Reno, Nevada was competed prior to entering the endodontic residency program at the Dental College of Georgia at Augusta University. He has participated in researching the effects of ultrasonics on the properties of glass ionomer cements with biomaterial scientist, Daniel Boyd. He is a co-author on the paper, "Primum non nocere - The effects of sodium hypochlorite on dentin as used in endodontics."

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Brian Bergeron

Program Director
Georgia Regents University College of Dental Medicine

Brian E. Bergeron, DMD serves as Associate Professor and Endodontics Residency Program Director at the Dental College of Georgia at Augusta University. He received his DMD from the University of Florida and completed a General Practice Residency at Offutt AFB, NE and a Residency in Endodontics at Wilford Hall Medical Center, Lackland AFB, San Antonio, TX. He served 23 years in the USAF Dental Corps, to include his final assignment as Endodontics Residency Director for the USAF program at Keesler AFB in Biloxi, MS. He is a Diplomate of the American Board of Endodontics and a Fellow in the International College of Dentists. He serves nationally on the ADA Dental Quality Alliance, the Scientific Advisory Board for the Journal of Endodontics, and as a Review Committee member for the Commission on Dental Accreditation.

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