Category: Monday Poster Session

P1152 - A Prospective Study Evaluating the Role of Homemade Yogurt as a Treatment Option for Irritable Bowel Disease

Monday, Oct 16
10:30 AM – 4:00 PM



Category: Functional Bowel Disease       

Manju Girish Chandran, MBBS1, Resmi Varghese, MBBS1, Anoop Jose Thoppil, MBBS1, Marina Joseph, MBBS1, Thomas Augustine, MD1, Roy Varghese, MD2
1ARH Hospital, Hyden, KY; 2University of Louisville, Hyden, KY
Introduction: Irritable bowel syndrom (IBS) is a functional disorder of the gastrointestinal (GI) tract, with no definite diagnostic test or treatment. Dysregulation of the gut - brain axis has been accepted as an important mechanism of IBS. Alterations in the stability and composition of gut microbiome is seen in patients with IBS.Manipulation of microbiota have shown to improve the symptoms in IBS patients[1]. We have hypothesized that daily consumption of homemade yogurt containing lactobacilli can supplant the GI microflora, and can be used for treating irritable bowel syndrome.

Methods: We prospectively included consecutive patients diagnosed with IBS, who consented for participation from January 2014 to May 2017 at two centers in Eastern Kentucky. IBS was categorized based on patient's predominant bowel habit . Handouts for homemade yogurt preparation from milk were provided,and patients were advised to take 2-3cups daily. Patients were followed up every 2 months for 6 months. Daily consumption of yogurt and symptom improvement were recorded on a self reported chart. Complete remission was defined as relief of pre existing IBS symptoms and 1-2 normal bowel movements per day.

Results: 189 patients with IBS were included in the study.All patients tolerated yogurt well. 5 patients discontinued therapy prior to 6 months(3 due to inconvenience; 2 due to unpleasant taste). Study population included predominantly females (63%) and the mean age of the cohort was 49yrs. 93% (169) of the cohort acheived complete remission with no side effects (Table 1). The average consumption was 2 cups per day in both groups. 46% of patients had previous coloscopy. Concomitant probiotics usage was 2.6% and not statistically significant in both cohorts. On logistic regression analysis, duration of yogurt consumption for at least 6 months was associated with complete remission (95% CI : 5.69 -6.51, p < 0.00001) (Figure 1).

Discussion: Contrary to the popular adage of avoiding milk based products in patients with IBS,our study is the first prospective study showing benefits of homemade yogurt for complete remission of IBS. Yogurt is a nutritious,preservative free, cost effective treatment option for IBS.

References: 1.Paul J Kennedy, Gerald Clarke. Irritable bowel syndrome: A gut microbiome-gut brain axis disorder ,WJG; 2014 Oct21;20(39):14105-14125

Supported by Industry Grant: No


Characteristics of patients with or without complete remission






































































Variables

Cohort with complete remission(n=169) Cohort without remission of symptoms(n=20)
Age(mean) 50 48
Male 37%(63) 25%(5)
Previous GI surgery 19%(33) 15%(3)
Family history of IBS 7.6%(13) 20%(4)
Duration of symptoms in years 9 10
Type of IBS C=41%(70)
D=37%(63)
C+D=22%(36)
C=30%(6)
D=45%(9)
C+D=25%(5)
Patients with colonoscopy 46%(79) 55%(11)
Average duration of yogurt consumption in months 13 8
Number of cups per day 2 2
Time for initial symptom relief in months 2 3
Use of concomitant probiotics 2.3%(4) 5%(1)
complications from treatment 0.59(1) 20(4)

IBS-Inflammatory Bowel Syndrome; C- Constipation; D -Diarrhea

Duration in months for complete remission of IBS

Citation: . A PROSPECTIVE STUDY EVALUATING THE ROLE OF HOMEMADE YOGURT AS A TREATMENT OPTION FOR IRRITABLE BOWEL DISEASE. Program No. P1152. World Congress of Gastroenterology at ACG2017 Meeting Abstracts. Orlando, FL: American College of Gastroenterology.

Manju Girish Chandran

Medical Extern and Research Associate
ARH Hospital
Hyden, Kentucky