Dissecting Single Cell and Tissue Heterogeneity at the Genome and Immunome Level

Saturday, June 17
1:00 PM - 1:25 PM

Garry P. Nolan

Rachford and Carlota Harris Professor
Stanford University

Dr. Nolan, Rachford and Carlota A. Harris Professor in the Department of Microbiology and Immunology at Stanford University School of Medicine. Trained with Leonard Herzenberg (Ph.D.) and Nobelist Dr. David Baltimore (postdoctoral work for the first cloning/characterization of NF-κB p65/RelA and the development of 293T rapid retroviral production systems). Published over 190 research papers, holds 17 US patents, and one of the top 25 inventors at Stanford University. Dr. Nolan’s areas of research include hematopoiesis, cancer and leukemia, autoimmunity and inflammation, and computational approaches for network and systems immunology. Recent efforts are focused on a single cell analysis advance using a mass spectrometry-flow cytometry hybrid device (CyTOF). The approach uses an advanced ion plasma source to determine the levels of tagged reagents bound to cells enabling a vast increase in the number of parameters that can be measured per cell. Another innovation is termed molecular ion beam imaging (MIBI) a system that also uses mass tags that will enable sub-light imaging (5 nm resolution) of tissue sections with 50 or more parameters per image. His laboratory has already begun a large scale mapping of the hematopoietic hierarchy in healthy human bone marrow at an unprecedented level of detail. Dr. Nolan’s efforts are directed to enable a deeper understanding not only of normal immune function, trauma, and other inflammatory events but also detailed substructures of leukemias and solid cancers — which will enable wholly new understandings that will enable better management of disease and clinical outcomes.


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William H. Robinson

Associate Professor
Stanford University

Dr. Robinson is an Associate Professor of Medicine at Stanford University, and a Staff Physician at VA Palo Alto. The Robinson laboratory works in the fields of B cell biology, autoimmunity and inflammation. Dr. Robinson pioneered development of protein arrays, lipid arrays, and most recently high-throughput sequencing approaches to identify the targets of antibody responses, investigate mechanisms underlying disease, and to develop novel therapeutic approaches. Dr. Robinson is the Director of the Stanford Osteoarthritis Initiative, PI of the NIH Stanford AMP Technology Center, and Co-Director of the Stanford-UCSF Arthritis Foundation Center of Excellence. He co-founded the Stanford Human Immune Monitoring Center, serves on the editorial boards of several journals, and serves on the Board of Directors of the American College of Rheumatology. He is an inventor on 23 patent applications, and technologies developed in his Stanford and VA laboratories have been licensed to nine companies in the biotechnology industry. Dr. Robinson was elected to the American Society for Clinical Investigation and the Henry Kunkel Society. Dr. Robinson received his MD and PhD degrees from Stanford University, and completed his clinical training in internal medicine at UCSF.


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David Hafler

William S. and Lois Stiles Edgerly Professor of Neurology and Immunobiology Chairman, Department of Neurology
Yale School of Medicine

Hafler is the William S. and Lois Stiles Edgerly Professor and Chairman Department of Neurology and Professor or Immunobiology, Yale School of Medicine, and is the Neurologist-in-Chief of the Yale-New Haven Hospital. He graduated in 1974 from Emory University , and the University of Miami School of Medicine in 1978. He then completed his internship at Hopkins followed by a neurology residency at Cornell Medical Cente. Dr. Hafler was trained in immunology at the Rockefeller University and then at Harvard where he joined the faculty in 1984 and later became the Breakstone Professorship of Neurology at Harvard and was a founding Associated Member of the Broad Institute at MIT. In 2009 he moved to Yale as the Chair of the Department of Neurology. Dr. Hafler is a clinical scientist with a research interest in the mechanism of MS with over 370 publications in the field of MS, and autoimmunity. He is a co-founder of the International MS Genetic Consortium a group that identified the genes causing MS. Dr. Hafler has bee elected to membership in the American Society of Clinical Investigation, AOA, and was a Weaver Scholar of the NMSS. He is a member of the editorial boards for JCI and the JEM, and is co-founder of FOCISs. Hafler was a Javits Merit Award Recipient from the NIH and has won many awards including 2010 Dystel Prize for MS research from the AAN, the Adams Prize in 2015 from the American Neurologic Association and the 2016 Frontier Lecturer at the AAN.


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Dissecting Single Cell and Tissue Heterogeneity at the Genome and Immunome Level

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