Immunity & infection

Poster

The Offspring Gestated in Hypothyroxinemia Develops a Poor Immune Response Against Respiratory Syncytial Virus

Wednesday, June 14
6:15 PM - 7:45 PM

Hypothyroxinemia (Hpx) is highly frequent condition in humans characterized by low levels of T4 and normal levels of T3 and TSH. We have shown that gestational Hpx significantly increases the severity of autoimmune encephalomyelitis experimental (EAE) increasing inflammatory cytokines in the blood, suggesting that the immune response could be altered in the offspring. We evaluated whether gestational Hpx could affect the immune response of the offspring against the infection with human respiratory syncytial virus (hRSV). We observed that the offspring gestated in Hpx and infected with RSV showed significantly weight loss, higher viral load and a higher infiltration of neutrophils correlating with a higher clinical score compared to the offspring gestated in euthyroidism. Moreover, it was detected a significant reduction in the infiltration of CD8+ T cells into the lung, as well as in the production of IFN-g and cytotoxic capacity, but without changes in IL-4, IL-10 and IL-6 production. Finally, in in vitro cultures of splenocytes from mice gestated under hypothyroxinemia, we observed a lower secretion of IFN-g in response to virus N protein in comparison to splenocytes from mice gestated under euthyroid conditions.


The support the notion that the progeny gestated in Hpx has altered its immune response. 

Evelyn L. Jara

Millennium Institute of Immunology and Immunotherapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile

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    Jorge A. Soto

    Millennium Institute of Immunology and Immunotherapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile
    Pontifical Catholic University of Chile

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      Natalia Muñoz-Durango

      Millennium Institute of Immunology and Immunotherapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile

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        Raquel Castellanos

        Departamento de Morfología, Facultad de Medicina, Universidad Andrés Bello

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          Susan Bueno

          Millennium Institute of Immunology and Immunotherapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile

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            Alexis M. M. Kalergis

            Titular professor
            Millennium Institute of Immunology and Immunotherapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile

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              Claudia Riedel

              Millenium Institute on Immunology and Immunotherapy, Departamento de Ciencias Biológicas, Facultad de Ciencias Biológicas y Facultad de Medicina, Universidad Andrés Bello

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