Transplantation

Oral

Pretransplant Expression of cd45rc on Blood T Cells to Predict Acute Allograft Rejection and Cancer in Kidney Transplantation: A Long-term Analysis

Thursday, June 15
5:45 PM - 7:00 PM

Pretransplant expression of CD45RC, expressed on CD8+ T cells has been associated with the risk of developing acute rejection (AR) at five years of follow-up in kidney transplant recipient (KTR). The objective of the present study was to analyze the relationship between pretranspalnt CD45RC expression on T cells and the post-transplant outcomes, including AR and cancer in the long-term follow-up.  


Methods. Pre-transplant expression of CD45RC on CD4+ and CD8+ circulating blood T cells was determined in a cohort of 89 consecutives, first time KTR. AR, cancers and deaths were retrospectively registered and characterized.  The relationship between frequencies of both CD4+ and CD8+CD45RC T cells subsets and post-transplant events was analyzed.


Results. AR, cancer and patient death occured in 20 (22.5%), 25 (28.1%) and 14 (15.7) patients, respectively after a mean follow-up of 11 years. Pre-transplant frequency of CD8+CD45RChigh T cells >54.3% was strongly associated with AR conferring a 4-7 fold increased risk after adjustment on classical risk factors. Cancer was associated with a decreased proportion of CD4+CD45RChigh T cells, with a frequency < 51.9% conferring a 3.5-5.5 increased risk of malignancy. Frequencies of CD4+ and CD8+CD45RChighT cells were positively correlated (p < 0.0001) suggesting that recipients at high AR risk display a low cancer risk.


Conclusion. Pre-transplant T cell expression of CD45RC is strongly associated with AR and cancer development in KTR. Thus, our results suggest that CD45RC appears as a double-edged sword biomarker of promising interest to assess both AR and cancer risk before kidney transplantation.

Jean-François Augusto

Angers University hospital

Presentation(s):

    Send Email for Jean-François Augusto

    Anne-Sophie Garnier

    Angers University Hospital

    Presentation(s):

      Send Email for Anne-Sophie Garnier

      Martin Planchais

      Angers University Hospital

      Presentation(s):

        Send Email for Martin Planchais

        Jean-François Subra

        Angers University Hospital

        Presentation(s):

          Send Email for Jean-François Subra

          Agnès Duveau

          Angers University Hospital

          Presentation(s):

            Send Email for Agnès Duveau

            Marie Lemerle

            Angers University Hospital

            Presentation(s):

              Send Email for Marie Lemerle

              Abdelhadi Saoudi

              UMR INSERM U1043

              Presentation(s):

                Send Email for Abdelhadi Saoudi

                Johnny Sayegh

                Angers University Hospital

                Presentation(s):

                  Send Email for Johnny Sayegh


                  Assets

                  Pretransplant Expression of cd45rc on Blood T Cells to Predict Acute Allograft Rejection and Cancer in Kidney Transplantation: A Long-term Analysis



                  Attendees who have favorited this

                  Send Email for Pretransplant Expression of cd45rc on Blood T Cells to Predict Acute Allograft Rejection and Cancer in Kidney Transplantation: A Long-term Analysis