Inflammatory bowel diseases

Poster

Microbial Metabolites Regulate Human T Cell Responses

Wednesday, June 14
6:15 PM - 7:45 PM

Microbial metabolites have strong potential to influence host immune responses. To advance the understanding of microbial functions on T cell responses, we screened a list of predicted differential abundant microbial metabolites in CD. Among 139 screened metabolites, we found 15 bioactive metabolites regulating CD4+ T cells through different actions, reflecting both proven and novel effects on human CD4+ T cells. We discovered twelve novel metabolites regulating T cell cytokine profiles with categorized actions, including pan-inhibition, pan-enhancement, and selective effects on cytokine productions. One novel microbe-derived molecule, ascorbate, selectively induced the apoptosis of activated human CD4+ T cells via modulating energy metabolism. Our findings demonstrate that microbial products can function as a metabolic modulator to influence host CD4+ T cell responses and this can be one novel microbial factors to influence CD progression.

Yu-Ling Chang

Molecular Biology IDP, University of California, Los Angeles

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    Maura Rossetti

    Pathology and Laboratory Medicine, University of California, Los Angeles

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      Hera Vlamakis

      The Broad Institute of MIT and Harvard

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        David Casero

        Pathology and Laboratory Medicine, University of California, Los Angeles

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          Gemalene Sunga

          Pathology and Laboratory Medicine, University of California, Los Angeles

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            Nicholas Harre

            Pathology and Laboratory Medicine, University of California, Los Angeles

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              Shelley Miller

              Pathology and Laboratory Medicine, University of California, Los Angeles

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                Romney Humphries

                Pathology and Laboratory Medicine, University of California, Los Angeles

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                  Thaddeus Stappenbeck

                  professor
                  Washington University School of Medicine, St. Louis

                  Thaddeus S. Stappenbeck M.D., Ph.D.
                  Professor
                  Department of Pathology and Immunology
                  Washington University School of Medicine
                  Saint Louis, Missouri 63110

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                    Kenneth Simpson

                    College of Veterinary Medicine, Cornell University

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                      R. Balfour Sartor

                      Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill

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                        Gary Wu

                        Division of Gastroenterology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania

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                          James Lewis

                          Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania

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                            Frederic Bushman

                            Department of Microbiology, Perelman School of Medicine, University of Pennsylvania

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                              Dermot McGovern

                              The F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center

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                                Nita Salzman

                                11Department of Microbiology and Molecular Genetics , Medical College of Wisconsin

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                                  James Borneman

                                  12Department of Plant Pathology and Microbiology, University of California, Riverside

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                                    Ramnik Xavier

                                    The Broad Institute of MIT and Harvard

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                                      Curtis Huttenhower

                                      The Broad Institute of MIT and Harvard

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                                        Jonathan Braun

                                        Pathology and Laboratory Medicine, University of California, Los Angeles

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