Autoimmune neurologic diseases

Oral

Gene Expression Profiles as Biomarkers for Secondary Progressive Multiple Sclerosis

Friday, June 16
6:15 PM - 7:30 PM

Multiple sclerosis (MS) is an autoimmune disease that targets the central nervous system. We and others have investigated for various biomarkers to predict the disease course in order to personalize treatment. There are some promising biomarkers for predicting relapses in relapsing remitting MS (RRMS) the most common type of MS, but very few for secondary progressive MS (SPMS). In contrast to SPMS, benign MS (BMS) is diagnosed primarily retrospectively and largely based on motor progression using the Expanded Disability Status Scale (EDSS). This study aims to identify gene expression changes between SPMS and BMS, as biomarkers for disease progression using blood samples from 21 SPMS and 13 BMS patients for RNA isolation. Microarray analysis was performed using Affymetrix GeneChip. Differential gene expression analysis was performed using limma package, and Gene Ontology was used for gene enrichment analysis comparing SPMS with BMS. Our results indicate that SPMS has a different gene expression profile than BMS. Using iPathwayGuide for pathway analysis, there were 12 of 115 differentially expressed genes identified in humoral immune response. Most interestingly, in the analysis of molecular function with iron ion binding, 7 out of all 79 genes were differentially expressed in SPMS versus BMS. Iron is essential for myelin formation and oxidative phosphorylation. Iron imbalance is associated with pro-inflammatory cytokines and oxidative stress. Therefore, our data suggest the role of humoral immunity and iron dysregulation in the pathogenesis of MS disease progression.

Joel Begay

University of Michigan School of Public Health - Department of Epidemiology

Presentation(s):

    Send Email for Joel Begay

    Qin Wang

    University of Michigan Department of Neurology

    Presentation(s):

      Send Email for Qin Wang

      Qi Wu

      University of Michigan Department of Neurology

      Presentation(s):

        Send Email for Qi Wu

        Catherine Dowling

        University of Michigan Department of Neurology

        Presentation(s):

          Send Email for Catherine Dowling

          Guangmei Mao

          University of Michigan Medical School - Department of Neurology

          Presentation(s):

            Send Email for Guangmei Mao

            America Ruiz

            University of Texas - San Antonio Department of Biology

            Presentation(s):

              Send Email for America Ruiz

              Ali Mirza

              University of Michigan Department of Immunology

              Presentation(s):

                Send Email for Ali Mirza

                Yang Mao-Draayer

                Associate Professor
                University of Michigan Department of Neurology

                Presentation(s):

                  Send Email for Yang Mao-Draayer


                  Assets

                  Gene Expression Profiles as Biomarkers for Secondary Progressive Multiple Sclerosis



                  Attendees who have favorited this

                  Send Email for Gene Expression Profiles as Biomarkers for Secondary Progressive Multiple Sclerosis